107967-06-6

Basic information

• Product Name: <2-(2-aminophenyl)-1-(4-methoxyphenyl)ethyl>propanedioic acid, dimethyl ester
• Synonyms: <2-(2-aminophenyl)-1-(4-methoxyphenyl)ethyl>propanedioic acid, dimethyl ester
• CAS NO: 107967-06-6
• Molecular Weight: 357.406
• Mol File: 107967-06-6.mol

Chemical Properties

• CAS DataBase Reference: <2-(2-aminophenyl)-1-(4-methoxyphenyl)ethyl>propanedioic acid, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: <2-(2-aminophenyl)-1-(4-methoxyphenyl)ethyl>propanedioic acid, dimethyl ester(107967-06-6)
• EPA Substance Registry System: <2-(2-aminophenyl)-1-(4-methoxyphenyl)ethyl>propanedioic acid, dimethyl ester(107967-06-6)

Safety Data

• Hazardous Substances Data: 107967-06-6(Hazardous Substances Data)

Upstream product

• 107967-05-5 [1-(4-Methoxyphenyl)-2-(2-nitrophenyl)ethyl]-propanedioic acid,dimethyl ester 
• 88-72-2 1-methyl-2-nitrobenzene 
• 7443-25-6 dimethyl 2-(4-methoxybenzylidene)malonate 

Downstream Products

• 129151-89-9 1,3,4,5-tetrahydro-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 
• 129151-90-2 1,3,4,5-tetrahydro-3-hydroxy-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 
• 129151-94-6 cis-3-(acetyloxy)-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one, monohydrochloride 
• 129151-93-5 cis-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one, monohydrochloride 
• 107967-08-8 1,3,4,5-tetrahydro-3-hydroxy-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 
• 129151-91-3 cis-1,3,4,5-tetrahydro-3-hydroxy-4-(methoxyphenyl)-2H-1-benzazepin-2-one 
• 129151-92-4 trans-1,3,4,5-tetrahydro-3-hydroxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 
• 129151-95-7 Acetic acid (3S,4R)-1-(2-dimethylamino-ethyl)-4-(4-methoxy-phenyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester 
• 107967-13-5 (3S,4R)-1-(2-Dimethylamino-ethyl)-3-hydroxy-4-(4-methoxy-phenyl)-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 

Relevant articles and documents

Benzazepinone calcium channel blockers. 2. Structure-activity and drug metabolism studies leading to potent antihypertensive agents. Comparison with benzothiazepinones

As part of a program to discover potent antihypertensive analogues of diltiazem (3a), we prepared 1-benzazepin-2-ones (4). Benzazepinones competitively displace radiolabeled diltiazem, and show the same absolute stereochemical preferences at the calcium channel receptor protein. Derivatives of 4 containing a trifluoromethyl substituent in the fused aromatic ring show potent and long-acting antihypertensive activity. Studies of the metabolism of 4 lead to the metabolically stable antihypertensive calcium channel blockers 5a and 5c. Benzazepinone 5a is a longer acting and more potent antihypertensive agent than the second generation diltiazem analogue TA-3090 (3e).

Benzazepinone calcium channel blockers. 4. Structure-activity overview and intracellular binding site

We have synthesized a series of benzazepinones (2) in order to determine the structure-activity relationships (SAR) for calcium channel blockers related to diltiazem. A prerequisite for calcium channel blocking activity in vitro and in vivo is the presenc

Benzazepine derivatives

Vasodilating activity is exhibited by compounds having the formula STR1 and pharmaceutically acceptable salts thereof.