129166-70-7

Upstream product

• 28276-32-6 ethyl p-mercaptobenzoate 
• 50-01-1 guanidine hydrochloride 
• 129166-69-4 ethyl 4-<(4-cyano-5-ethoxy-5-oxopentyl)thio>benzoate 
• 129166-68-3 ethyl 4-<(3-bromopropyl)thio>benzoate 
• 20057-83-4 diethyl 4,4'-dithiobis 

Downstream Products

• 129166-71-8 4-<<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>thio>benzoic acid 
• 129166-72-9 diethyl N-<4-<<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>thio>benzoyl>-L-glutamate 
• 129166-73-0 N-<4-<<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>thio>benzoyl>-L-glutamic acid 

Relevant academic research and scientific papers

Synthesis and biological activity of open-chain analogues of 5,6,7,8- tetrahydrofolic acid-potential antitumor agents

This study describes the synthesis and in vitro antitumor activity of inhibitors of purine de novo biosynthesis that are analogues of N-[4-[[3- (2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]amino]benzoyl-L-glutamic acid (5-DACTHF). Benzene ring subs

Substituted glutamic acids

The present invention provides a compound of formula (I): STR1 wherein Y is sulfur; R2 and R3 are the same or different and are hydrogen or C1-4 alkyl; R4 is NR11 R12 ; R11, R12, R5 and R6 are the same or different and are hydrogen, C1-4 alkyl or C1-12 acyl; R7, R8, R9 and R10 are the same or different and are hydrogen, halo, C1-4 haloalkyl, C1-4 alkyl and C1-4 alkoxy; and n is 2, 3, 4 or 5; m is 0 or an integer from 1 to 5; or a salt thereof, methods for the preparation of the compounds of the formula (I), intermediates in their preparations, pharmaceutical formulations containing them, and their use in the treatment of neoplastic growth.