129180-58-1Relevant academic research and scientific papers
Improved Synthesis of Aryl 1,1-Dimethylpropargyl Ethers
Godfrey, Jollie D.,Mueller, Richard H.,Sedergran, Thomas C.,Soundarajan, Nachimuthu,Colandrea, Vincent J.
, p. 6405 - 6408 (1994)
An efficient, general, and practical synthesis of aryl 1,1-dimethylpropargyl ethers has been developed.
Copper-catalyzed intramolecular carbotrifluoromethylation of alkynes for the construction of trifluoromethylated heterocycles
Wang, Yanan,Jiang, Min,Liu, Jin-Tao
supporting information, p. 15315 - 15319 (2016/02/18)
A mild and efficient copper-catalyzed intramolecular carbotrifluoromethylation of alkynes has been achieved in the presence of Togni reagent as trifluoromethylating reagent. The reaction tolerates a range of substrates to give a group of trifluoromethylated heterocycles with high selectivities. A plausible mechanism was proposed on the basis of experimental results. And the Togni award goes to Copper-catalyzed intramolecular carbotrifluoromethylation of alkynes is carried out with a Togni reagent as the trifluoromethylating reagent (see scheme). Various trifluoromethylated heterocycles are synthesized in moderate to good yields. Moreover, a range of common functional groups is tolerated under the reaction conditions.
Phosphinic ester substituted benzopyran derivatives
-
, (2008/06/13)
STR1 and pharmaceutically acceptable salts thereof wherein Y is a single bond, --CH 2 --, --C(O)--, --S-- or --N(R 11)--; and R 1 to R 6 are as defined herein. These compounds have potassium channel activating activity and are useful, therefore for example, as cardiovascular agents.
Copper(I) iodide: A catalyst for the improved synthesis of aryl propargyl ethers
Bell,Davies,Geen,Mann
, p. 707 - 712 (2007/10/02)
Copper(I) iodide catalyses the reaction between phenols and dialkylpropargyl chlorides to give aryl 1,1-dialkylpropargyl ethers 5 a-k and 7a-e in good yields and purity. These ethers are important as precursors to the 2H-1-benzopyrans 8a-l and 9a-e.
Benzopyran derivatives and antihypertensive use thereof
-
, (2008/06/13)
Disclosed herein are novel benzopyrans having pharmacological activity, to a process for preparing them, to pharmaceutical compositions containing them, and to their use in the treatment of hypertension.
