129196-80-1Relevant academic research and scientific papers
Nickel-catalyzed: C-alkylation of thioamide, amides and esters by primary alcohols through a hydrogen autotransfer strategy
Yang, Peng,Wang, Xiuhua,Ma, Yu,Sun, Yaxin,Zhang, Li,Yue, Jieyu,Fu, Kaiyue,Zhou, Jianrong Steve,Tang, Bo
supporting information, p. 14083 - 14086 (2020/11/20)
A simple catalyst of Ni(OAc)2 and P(t-Bu)3 enables selective C-alkylation of thioacetamides and primary acetamides with alcohols for the first time. Monoalkylation of thioamides, amides and t-butyl esters occurs in excellent yields (>95%). Mechanistic studies reveal that the reaction proceeds via a hydrogen autotransfer pathway. This journal is
QUINOLONES USEFUL AS INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS
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, (2008/12/06)
The present invention relates to novel quinolones of Formula I that inhibit inducible NOS synthase together with methods of synthesizing and using the compounds including methods for inhibiting or modulating nitric oxide synthesis and/or lowering nitric oxide levels in a patient by administering the compounds for the treatment of disease.
Synthesis of Optically Active Amides from β-Furyl and β-Phenyl Esters by way of Enzymatic Aminolysis
Gotor, Vicente,Menendez, Emma,Mouloungui, Zephirin,Gaset, Antoine
, p. 2453 - 2456 (2007/10/02)
Candida antarctica lipase efficiently catalyses the aminolysis of non-activated esters with a β-furyl or β-phenyl group; use of racemic amines gives the corresponding optically active amides with high enantiomeric axcess.
Nickel(0) induzierte und katalysierte CC-Verknuepfungen zwischen Phenylisocyanat und vinylsubstituierten Heteroaromaten
Hoberg, Heinz,Guhl, Dieter,Betz, Peter
, p. 233 - 246 (2007/10/02)
Vinyl substituted heterocycles such as 2-vinylfuran (Ia) and 2-vinylpyridine (Ib) react with phenylisocyanate (II) in presence of (Lig)Ni0 (Lig = TCP) to form the tricyclohexylphosphane-5-azanickelacyclopentan-4-one derivatives (V).The structures and properties of these metallacycles are described.A catalytic 1/1 CC bond formation to give the α,β-unsaturated carboxylic acid amide X proceeds only with Ia (Lig = P(OiP)3) and not with Ib (Lig = PEt3, PPh3, P(OiP)3).Presumably, the different reactivities are not caused by electronic and/or steric factors of the 2-furyl- or 2-pyridyl-substituents, but by the donor properties of the N-atom in Ib.The N Ni interactions in the complex bis2-2-vinyl-μ-pyridine-nickel> (XIIb) can be detected by spectroscopic and crystal structure studies.
