129217-16-9

Upstream product

• 129217-15-8 (1R*)-6(R*)-bromocyclohex-2-enyl benzoylcarbamate 
• 129263-14-5 3a,4,5,7a-tetrahydrobenzo[d]oxazol-2(3H)-one 
• 98-88-4 benzoyl chloride 
• 4461-33-0 benzoyl isocyanate 
• 53921-01-0 trans-Bromo-4-hydroxy-3-cyclohexen 
• 91230-16-9 3-(N-tert-butoxycarbonylamino)cyclohexene 
• 1165952-91-9 cyclohexa-1,3-diene 

Relevant academic research and scientific papers

Palladium-catalyzed formation and stereoselective isomerization of 5- vinyloxazolines. Application to the formal synthesis of (S,S)-4-amino-3- hydroxy-5-phenylpentanoic acid

Vinyloxazolidinones have been found to undergo Pd(0)-catalyzed ionization followed by loss of carbon dioxide and subsequent cyclization to form vinyloxazolines. The reaction occurred under mild conditions, and enhancement of diastereomeric ratios with chiral substrates was obtained. 4- Benzyl-5-vinyloxazoline prepared by this method has been utilized in the stereoselective synthesis of (S,S)-4-amino-3-hydroxy-5-phenylpentanoic acid (AHPPA).

N-BENZOYLCARBAMATE CYCLIZATIONS

The anion of an alcohol derived N-benzoylcarbamate may be used to deliver nitrogen intramolecularly to electrophilic centers.This allows the stereocontrolled synthesis of a variety of amino-alcohol and amino-diol derivatives.