129227-48-1Relevant academic research and scientific papers
Synthesis and anticonvulsant activity of some new pyrazolo[3,4-b]pyrazines and related heterocycles
Farghaly, Abdel-Rahman,Esmail, Sabah,Abdel-Zaher, Ahmed,Abdel-Hafez, Ali,El-Kashef, Hussein
, p. 2166 - 2175 (2014/04/17)
A series of new pyrazolo[3,4-b]pyrazines containing, 1,2,4-oxadiazolyl, thiadiazolyl, imidazothiadiazolyl, thiazolidinonyl, substituents and other different substituents, was synthesized using 1,6-diphenyl-3-methyl-lH- pyrazolo[3,4-b]pyrazine-5-carbonitrile (2) as a starting material. Some of the newly prepared compounds were evaluated for their anticonvulsant activity. Compounds 9a, 13a-d and 14a at a dose of 10 mg/kg showed very significant anticonvulsant activity and increased the latency time of PTZ-induced tonic seizures. Compound 9b showed significant effect.
