1292297-05-2

Upstream product

• 13252-84-1 4-hydroxy-6-methoxycoumarin 
• 705-15-7 1-(2-hydroxy-5-methoxyphenyl)ethan-1-one 
• 1388149-01-6 C₁₉H₁₈O₆ 
• 1225441-53-1 4-methoxy-3-(methoxymethoxy)phenylboronic acid 
• 243990-54-7 (3-(benzyloxy)-4-methoxyphenyl)boronic acid 
• 78504-28-6 2-Benzyloxy-4-bromo-1-methoxybenzene 
• 638191-28-3 trifluoromethanesulfonic acid 6-methoxy-2-oxo-2H-chromen-4-yl ester 
• 622864-48-6 (3-hydroxy-4-methoxyphenyl)boronic acid 

Downstream Products

• 1388149-07-2 dibenzyl [2-methoxy-5-(6-methoxy-2-oxochromen-4-yl)phenyl]phosphate 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 4 arylcoumarin analogues as tubulin-targeting antitumor agents

The synthesis of twenty-six 4-arylcoumarin analogues of combretastatin A-4 (CA-4) led to the identification of two new compounds (25 and 26) with strong cytotoxic activity. Both compounds had a high cytotoxic effect on a CA-4-resistant colon adenocarcinoma cell line (HT29D4). The compounds affected cell cycle progression characterized by a mitotic block. The activity of these compounds against microtubules both in vitro and in cells was examined and both compounds were found to potently inhibit in vitro microtubule formation via a sub-stoichiometric mode like CA-4. By immunofluorescence, it was observed that both compounds induced strong microtubule network disruption. Our results provide a strong experimental basis to develop new potent anti-tubulin molecules targeting CA-4-resistant cancer cells.

Synthesis of hydrophilic and lipophilic 4-arylcoumarin phosphates

Novel hydrophilic and lipophilic prodrugs, sodium 4-arylcoumarin dialkylphosphates and 4-arylcoumarin dioleyl phosphates, were synthesized by phosphorylation of 4-arylcoumarins with dialkylphosphites.

Synthesis and biological evaluation of 4-arylcoumarin analogues of combretastatins. Part 2

Figure Presented. A series of A-ring variously methoxylated 4-(3-hydroxy-4-methoxyphenyl)coumarins related to combretastatin A-4 was prepared by cross-coupling reactions. Cytotoxicity studies indicated a potent activity against HBL100 cell line. Substitut