1292298-06-6Relevant academic research and scientific papers
Selective treatment of hypoxic tumor cells in vivo: Phosphate pre-prodrugs of nitro analogues of the duocarmycins
Tercel, Moana,Atwell, Graham J.,Yang, Shangjin,Ashoorzadeh, Amir,Stevenson, Ralph J.,Botting, K. Jane,Gu, Yongchuan,Mehta, Sunali Y.,Denny, William A.,Wilson, William R.,Pruijn, Frederik B.
, p. 2606 - 2609 (2011/05/04)
Hitting the hypoxic target: Combining a nitro prodrug with a water-soluble phosphate converts duocarmycin analogues from highly toxic DNA-alkylating agents to highly selective antitumor compounds. These prodrugs (see scheme) have outstanding activity agai
