1292317-54-4

Usage

Uses

Used in Pharmaceutical Industry:
2-(tetrahydro-2H-pyran-4-yloxy)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is used as a building block for the synthesis of pharmaceutical compounds due to its diverse functional groups that can be utilized in the development of new drugs.
Used in Materials Science:
In the field of materials science, 2-(tetrahydro-2H-pyran-4-yloxy)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is used as a precursor for the creation of new materials with unique properties, such as improved stability or reactivity.
Used in Organic Synthesis:
2-(tetrahydro-2H-pyran-4-yloxy)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is used as an intermediate in organic synthesis for the production of various organic compounds, taking advantage of its reactive functional groups to form new chemical bonds and structures.
Further research and testing would be required to fully understand the potential uses and properties of 2-(tetrahydro-2H-pyran-4-yloxy)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile, as its complex structure may offer novel applications in different industries.

Upstream product

• 2081-44-9 Tetrahydro-pyran-4-ol 
• 179897-89-3 5-Bromo-2-fluoro-benzonitrile 
• 876918-62-6 5-bromo-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile 
• 73183-34-3 bis(pinacol)diborane 
• 40530-18-5 5-bromo-2-hydroxybenzonitrile 

Downstream Products

• 1292317-55-5 5-(2-chloropyrimidin-4-yl)-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile 
• 1292317-80-6 4-({4-[3-cyano-4-(tetrahydro-2H-pyran-4-yloxy)phenyl]pyrimidin-2-yl}amino)-2-methoxybenzoic acid 
• 1292310-49-6 5-[2-[(4-morpholinophenyl)amino]pyrimidin-4-yl]-2-tetrahydropyran-4-yloxy-benzonitrile 
• 1292315-72-0 5-[2-[[4-(hydroxymethyl)-3-methoxy-phenyl]amino]pyrimidin-4-yl]-2-tetrahydropyran-4-yloxy-benzonitrile 
• 1292315-74-2 5-[2-[[4-(imidazol-1-ylmethyl)phenyl]amino]pyrimidin-4-yl]-2-tetrahydropyran-4-yloxy-benzonitrile 
• 1292312-86-7 methyl 4-[[4-(3-cyano-4-tetrahydropyran-4-yloxy-phenyl)pyrimidin-2-yl]amino]-2-methoxy-benzoate 
• 1403246-79-6 5-[2-({6-[(2-hydroxyethyl)(methyl)amino]pyridin-3-yl}amino)pyrimidin-4-yl]-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile 
• 1403247-76-6 5-(2-{[5-(morpholin-4-yl)pyridin-2-yl]amino}pyrimidin-4-yl)-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile 
• 1403247-78-8 5-{2-[(5-{[4-(2-hydroxyethyl)piperazin-1-yl]carbonyl}thiophen-2-yl)amino]pyrimidin-4-yl}-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile 
• 1426921-18-7 5-(2-chloropyridin-4-yl)-2-(tetrahydropyran-4-yloxy)benzonitrile 

Relevant academic research and scientific papers

TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF

The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKKε inhibitors.

TANK-BINDING KINASE INHIBITOR COMPOUNDS

Compounds having the following formula (I) and methods of their use and preparation are disclosed:

TANK-BINDING KINASE INHIBITOR COMPOUNDS

Compounds having the following formula (I) and methods of their use and preparation are disclosed:

COMPOUNDS, COMPOSITIONS, AND THERAPEUTIC USES THEREOF

The invention relates to compounds, pharmaceutical compositions and medicaments comprising such compounds, and the use of these compounds, compositions, and medicaments in methods of treating a variety of diseases and disorders.

BENZONITRILE DERIVATIVES AS KINASE INHIBITORS

Compounds of the formula I, in which R1, R2, X and Y have the meanings indicated in Claim 1, are inhibitors of TBK1 and IKKε and can be employed, inter alia, for the treatment of cancer and inflammatory diseases.

FURO [3, 2 - B] - AND THIENO [3, 2 - B] PYRIDINE DERIVATIVES AS TBK1 AND IKK INHIBITORS

Compounds of the formula (I) in which R1, R2 and X have the meanings indicated in Claim 1, are inhibitors of TBK1 and ΙΚΚε and can be employed, inter alia, for the treatment of cancer and inflammatory diseases.

COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS

The invention relates to compounds, pharmaceutical compositions and medicaments comprising such compounds, and the use of these compounds, compositions, and medicaments in methods of treating diseases and disorders.

AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBK1 AND/OR IKK EPSILON

The invention relates to certain aminopyrimidine compounds which inhibit TBK1 and/or IKK epsilon and which may therefore find application in treating inflammation, cancer, septic shock and/or Primary open Angle Glaucoma (POAG).