1292310-49-6

Basic information

• Product Name: IKK epsilon-IN-1
• Synonyms: IKK epsilon-IN-1;IKKε-IN-1;5-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile IKKε-IN-1;5-(2-((4-Morpholinophenyl)Amino)Pyrimidin-4-Yl)-2-((Tetrahydro-2H-Pyran-4-Yl)Oxy)Benzonitrile
• CAS NO: 1292310-49-6
• Molecular Formula: C₂₆H₂₇N₅O₃
• Molecular Weight: 457.52428
• Product Categories: API
• Mol File: 1292310-49-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 727.2±70.0 °C(Predicted)
• Appearance: /
• Density: 1.32±0.1 g/cm3(Predicted)
• PKA: 5.25±0.40(Predicted)
• CAS DataBase Reference: IKK epsilon-IN-1(CAS DataBase Reference)
• NIST Chemistry Reference: IKK epsilon-IN-1(1292310-49-6)
• EPA Substance Registry System: IKK epsilon-IN-1(1292310-49-6)

Safety Data

• Hazardous Substances Data: 1292310-49-6(Hazardous Substances Data)

Usage

Uses

TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.

Upstream product

• 1292317-54-4 2-((tetrahydro-2H-pyran-4-yl)oxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 
• 876918-62-6 5-bromo-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile 
• 40530-18-5 5-bromo-2-hydroxybenzonitrile 
• 2524-67-6 4-morpholino-4-yl-phenylamine 
• 1292317-55-5 5-(2-chloropyrimidin-4-yl)-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile 
• 179897-89-3 5-Bromo-2-fluoro-benzonitrile 
• 2081-44-9 Tetrahydro-pyran-4-ol 

Relevant articles and documents

AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBK1 AND/OR IKK EPSILON

The invention relates to certain aminopyrimidine compounds which inhibit TBK1 and/or IKK epsilon and which may therefore find application in treating inflammation, cancer, septic shock and/or Primary open Angle Glaucoma (POAG).