129285-84-3Relevant academic research and scientific papers
Cyclic oxonium ylides: Building blocks for iterative synthesis of polycyclic ethers
Marms?ter, Fredrik P,Vanecko, John A,West
, p. 2027 - 2040 (2007/10/03)
A series of diazoketones bearing remote benzyl or allyl ethers was subjected to a variety of conditions for catalytic diazodecomposition and cyclic oxonium ylide formation as a possible method for polycyclic ether synthesis. Allyl ethers 19, 25 and 29 und
A simple convergent method for the construction of fused tri- and tetracyclic ethers
Fujiwara, Kenshu,Saka, Kimiko,Takaoka, Daisuke,Murai, Akio
, p. 1037 - 1040 (2007/10/03)
Starting from monocyclic ethereal aldehyde and dithioacetal S-oxide segments, trans-fused tri- and tetracyclic ethers were synthesized in high yields in short steps involving acetal cyclization and reductive etherification reactions. This sequence could offer a simple convergent approach to the synthesis of natural trans-fused polycyclic ethers.
Synthesis of medium-sized ring ethers from thionolactones, applications to polyether synthesis
Nicolaou,McGarry,Somers,Kim,Ogilvie,Yiannikouros,Prasad,Veale,Hark
, p. 6263 - 6276 (2007/10/02)
A variety of medium-sized thionolactones have been prepared and condensed with nucleophiles giving alkylated thioacetals upon quenching with methyl iodide. Reductive desulfurization using triphenyltin hydride under radical conditions afforded the corresponding cyclic ethers rapidly and efficiently and, in most cases, with complete stereocontrol. This methodology has been proven through the construction of model systems of rings B and D of brevetoxin A (1) and a synthesis of (±)-lauthisan (44).
