129303-82-8

Usage

General Description

1-phenyl-1H-[1,2,3]triazolo[4,5-c]pyridine, also known as Cymbidazol, is a heterocyclic compound with a molecular formula C11H8N4. This chemical is commonly used in the pharmaceutical industry as a potential antitumor and antiviral agent. It is structurally similar to purine bases and has been investigated for its potential inhibitory effects on enzymes involved in DNA replication and repair. Additionally, 1-phenyl-1H-[1,2,3]triazolo[4,5-c]pyridine has shown potential in the treatment of certain viral infections by targeting viral RNA polymerase. The unique chemical structure and potential biological activities make 1-phenyl-1H-[1,2,3]triazolo[4,5-c]pyridine an interesting candidate for further research and development in the field of medicinal chemistry.

Upstream product

• 35750-90-4 4-(N-phenylamino)-3-nitropyridine 
• 13091-23-1 4-chloro-3-nitropyridine 
• 62-53-3 aniline 
• 273-05-2 1H-[1.2.3]triazolo-(4,5-c)pyridine 
• 591-50-4 iodobenzene 
• 35826-31-4 3-amino-4-(phenylamino)pyridine 

Downstream Products

• 858840-30-9 1-(4-nitro-phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine 
• 129303-85-1 4-Methyl-1-phenyl-1H-[1,2,3]triazolo[4,5-c]pyridine 
• 129320-56-5 2-Methyl-1-(1-phenyl-1H-[1,2,3]triazolo[4,5-c]pyridin-4-yl)-propan-2-ol 
• 98175-84-9 1-phenyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridine 
• 94934-78-8 5-methyl-1-phenyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridine 

Relevant academic research and scientific papers

Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists

We describe the synthesis and SAR of 1,2,3-triazolopiperidines as a novel series of potent, brain penetrant P2X7 antagonists. Initial efforts yielded a series of potent human P2X7R antagonists with moderate to weak rodent potency, some CYP inhibition, poo

BICYCLIC HETEROCYCLIC DERIVATIVES

Compounds of the formula la or of the formula lb in which X, Y, R1 and R2 have the meanings indicated in Claim 1, are inhibitors of pyruvate dehydrogenase kinase (PDHK), and can be employed, inter alia, for the treatment of diseases

P2X7 MODULATORS

The present invention is directed to compounds of Formulas (I, IIa and IIb): The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, IIa and IIb). Methods of making and using the compounds of Formulas (I, IIa and IIb) are also within the scope of the invention.