1293363-13-9

Upstream product

• 16062-69-4 2-propyl-4H-benzo[d][1,3]oxazin-4-one 
• 100-63-0 phenylhydrazine 
• 118-92-3 anthranilic acid 
• 6328-94-5 2-[(1-oxobutyl)amino]benzoic acid 
• 118-48-9 isatoic anhydride 
• 43083-12-1 1,1,1-trimethoxybutane 

Relevant academic research and scientific papers

Design, synthesis and antibacterial evaluation of 2-alkyl- and 2-aryl-3-(phenylamino)quinazolin-4(3H)-one derivatives

2-Alkyl and 2-aryl-3-(phenylamino)quinazolin-4(3H)-ones 4a-h were synthesized in a one-pot three-component condensation of an isatoic anhydride 1a-h, ethyl or methyl ortho ester and phenylhydrazine in the presence of KAl(SO4)2·12H2O (alum) as a nontoxic, reusable, inexpensive and easily available catalyst. The synthesis was conducted under microwave irradiation or classical heating. Products 4a and 4b show good antimicrobial activities.

Synthesis of a novel series of 2,3-disubstituted quinazolin-4(3H)-ones as a product of a nucleophilic attack at C(2) of the corresponding 4H-3,1-benzoxazin-4-one

A new series of 2,3-disubstituted quinazolin-4(3H)-one derivatives was synthesized by nucleophilic attack at C(2) of the corresponding key starting material 2-propyl-4H-3,1-benzoxazin-4-one (Scheme 2). The reaction proceeded via amidinium salt formation (Scheme 3) rather than via an N-acylanthranilimide. The structure of the prepared compounds were elucidated by physical and spectral data like FTIR, 1H-NMR, and mass spectroscopy.