1293397-32-6

Basic information

• Product Name: C₂₉H₃₅N₇O₇
• Synonyms: C₂₉H₃₅N₇O₇
• CAS NO: 1293397-32-6
• Molecular Weight: 593.64
• Mol File: 1293397-32-6.mol

Chemical Properties

• CAS DataBase Reference: C₂₉H₃₅N₇O₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₃₅N₇O₇(1293397-32-6)
• EPA Substance Registry System: C₂₉H₃₅N₇O₇(1293397-32-6)

Safety Data

• Hazardous Substances Data: 1293397-32-6(Hazardous Substances Data)

Upstream product

• 86770-67-4 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol 
• 357262-96-5 4-benzoyl-2-(R)-methyl-1-[(4-nitro-7-oxido-1H-pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]piperazine 

Downstream Products

• 1430096-72-2 C₅₁H₆₄N₈O₁₄ 

Relevant articles and documents

Chemically programmed antibodies as HIV-1 attachment Inhibitors

Herein, we describe the design and application of two small-molecule anti-HIV compounds for the creation of chemically programmed antibodies. N-Acyl-β-lactam derivatives of two previously described molecules BMS-378806 and BMS-488043 that inhibit the interaction between HIV-1 gp120 and T-cells were synthesized and used to program the binding activity of aldolase antibody 38C2. Discovery of a successful linkage site to BMS-488043 allowed for the synthesis of chemically programmed antibodies with affinity for HIV-1 gp120 and potent HIV-1 neutralization activity. Derivation of a successful conjugation strategy for this family of HIV-1 entry inhibitors enables its application in chemically programmed antibodies and vaccines and may facilitate the development of novel bispecific antibodies and topical microbicides.

BIFUNCTIONAL MOLECULES WITH ANTIBODY-RECRUITING AND ENTRY INHIBITORY ACTIVITY AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS

The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as ARM-H′ function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and b