1430096-72-2

Basic information

• Product Name: C₅₁H₆₄N₈O₁₄
• Synonyms: C₅₁H₆₄N₈O₁₄
• CAS NO: 1430096-72-2
• Molecular Weight: 1013.11
• Mol File: 1430096-72-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₅₁H₆₄N₈O₁₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₁H₆₄N₈O₁₄(1430096-72-2)
• EPA Substance Registry System: C₅₁H₆₄N₈O₁₄(1430096-72-2)

Safety Data

• Hazardous Substances Data: 1430096-72-2(Hazardous Substances Data)

Upstream product

• 86770-67-4 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol 
• 357262-96-5 4-benzoyl-2-(R)-methyl-1-[(4-nitro-7-oxido-1H-pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]piperazine 
• 1293397-32-6 C₂₉H₃₅N₇O₇ 
• 1430096-70-0 1-(4-(2,5,8,11,14-pentaoxaheptadec-16-yn-1-yl)benzoyl)azetidin-2-one 
• 1430097-02-1 methyl 4-(2,5,8,11,14-pentaoxaheptadec-16-yn-1-yl)benzoate 
• 87450-10-0 3,6,9,12-tetraoxapentadec-14-yn-1-ol 
• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 1430097-04-3 4-(2,5,8,11,14-pentaoxaheptadec-16-yn-1-yl)benzoic acid 

Relevant articles and documents

Chemically programmed antibodies as HIV-1 attachment Inhibitors

Herein, we describe the design and application of two small-molecule anti-HIV compounds for the creation of chemically programmed antibodies. N-Acyl-β-lactam derivatives of two previously described molecules BMS-378806 and BMS-488043 that inhibit the interaction between HIV-1 gp120 and T-cells were synthesized and used to program the binding activity of aldolase antibody 38C2. Discovery of a successful linkage site to BMS-488043 allowed for the synthesis of chemically programmed antibodies with affinity for HIV-1 gp120 and potent HIV-1 neutralization activity. Derivation of a successful conjugation strategy for this family of HIV-1 entry inhibitors enables its application in chemically programmed antibodies and vaccines and may facilitate the development of novel bispecific antibodies and topical microbicides.