129374-75-0

Upstream product

• 124156-28-1 cis-3-isopropyl-1-(4-methoxyphenyl)-4-oxoazetidine-2-carboxylic acid 
• 124156-26-9 cis-3-Isopropyl-4-(methoxycarbonyl)-1-(4-methoxyphenyl)azetidin-2-one 
• 124156-27-0 ethyl 3-isopropyl-1-(4-methoxyphenyl)-4-oxoazetidin-2-carboxylate 
• 124156-27-0 cis-1-p-anisyl-3-isopropyl-4-carbethoxy-2-azetidinone 
• 108-12-3 isopentanoyl chloride 
• 124156-20-3 (4-methoxyphenyl-benzylidene)-carbamic acid methyl ester 
• 24978-42-5 1,4-bis(4'-methoxyphenyl)-1,4-diazabuta-1,3-diene 
• 133505-01-8 cis-1-(p-methoxyphenyl)-3-isopriopyl-4-formyl-2-azetidinone 

Downstream Products

• 133505-01-8 cis-1-(p-methoxyphenyl)-3-isopriopyl-4-formyl-2-azetidinone 
• 129374-88-5 2-Hydroxy-2-((2S,3R)-3-isopropyl-2-methanesulfonyloxymethyl-4-oxo-azetidin-1-yl)-3-oxo-butyric acid benzyl ester 
• 136582-28-0 trans-benzyl 3-hydroxy-2-<2-oxo-3-isopropyl-4-(methylsulfonyloxymethyl)azetidin-1-yl>but-2-enoate 
• 129374-68-1 trans-benzyl 7-isopropyl-3-methyl-2-isocephem-4-carboxylate 
• 129374-66-9 benzyl (+/-)-trans-7-isopropyl-3-methyl-2-isoxacephem-4-carboxylate 
• 129374-88-5 2-Hydroxy-2-((2S,3S)-3-isopropyl-2-methanesulfonyloxymethyl-4-oxo-azetidin-1-yl)-3-oxo-butyric acid benzyl ester 
• 136582-28-0 cis-benzyl 3-hydroxy-2-<2-oxo-3-isopropyl-4-(methylsulfonyloxymethyl)azetidin-1-yl>but-2-enoate 
• 129374-68-1 cis-benzyl 7-isopropyl-3-methyl-2-isocephem-4-carboxylate 
• 129374-66-9 cis-benzyl 7-isopropyl-3-methyl-2-iso-oxacephem-4-carboxylate 

Relevant academic research and scientific papers

Simple and Condensed β-Lactams 12. Alternative Entry into the 2-Isocephem and 2-Iso-oxacephem Series.

The N-Unsubstituted-2-azetidinones ( 17a,b) react smoothly with esters of 2,3-dioxobutyric acid.In resulting intermediates (29b; 30a,b) were converted into the acetoacetates (33b; 34a,b) which were cyclized and deprotected to give the 2-iso-oxacephem- and 2-isocephem-4-carboxylic acids (1a,b) and (2a,b).