129398-69-2

Upstream product

• 51927-46-9 1-bromomethyl-4-methanesulfinylbenzene 
• 73285-38-8 Z(OM₄e)-Met(O)-OH 
• 3446-90-0 4-(methylthio)benzyl alcohol 
• 38185-19-2 4-(methylthio)benzyl bromide 

Downstream Products

• 129398-73-8 Boc-Tyr(Msib)-Gly-Gly-Phe-Met(O)-OMsib 
• 129398-74-9 Boc-Tyr(Mtb)-Gly-Gly-Phe-Met-OMtb 
• 129398-72-7 Z(OMe)-Gly-Gly-Phe-Met(O)-OMsib 
• 129398-71-6 Z(OMe)-Gly-Phe-Met(O)-OMsib 
• 129398-70-5 Z(OMe)-Phe-Met(O)-OMsib 

Relevant academic research and scientific papers

Sulphur Trioxide/Thiol: A Novel System for the Reduction of Methionine Sulphoxide

A new method for the effective reduction of methionine sulphoxide in protected peptides with sulphur trioxide and thiol has been developed.In practice, a combination of dimethylformamide-sulphur trioxide complex and ethane-1,2-dithiol was found effective, the presence of pyridine in the reaction medium being found necessary for the reduction to proceed.Methionine sulphoxide in two types of protected methionine-enkephalins was efficiently reduced to methionine by this reduction system at 20 deg C in an hour.The (p-methylsulphinyl)benzyl protecting group was also reduced to (p-methylthio)benzyl simultaneously with the reduction of methionine sulphoxide.Subsequent deprotection afforded methionine-enkephalin of high purity in each case.