1294479-59-6Relevant academic research and scientific papers
Highly enantioselective synthesis of anti aryl β-hydroxy α-amino esters via DKR transfer hydrogenation
Liu, Zhuqing,Shultz, C.Scott,Sherwood, Candice A.,Krska, Shane,Dormer, Peter G.,Desmond, Richard,Lee, Claire,Sherer, Edward C.,Shpungin, Joseph,Cuff, James,Xu, Feng
, p. 1685 - 1688 (2011)
An efficient preparation of highly enantiomerically enriched aryl β-hydroxy α-amino esters via dynamic kinetic resolution (DKR), asymmetric transfer hydrogenation of α-amino β-keto esters is described. The anti β-hydroxyl α-amino esters were obtained both in high yields and high diasteroselectivity. The observed high anti selectivity is inconsistent with the previous results in literature. The absolute stereochemistry of the aryl β-hydroxy α-amino esters was unambiguously confirmed via chemical derivatization as well as Vibrational Circular Dichroism (VCD) techniques.
