151870-52-9Relevant articles and documents
A practical synthesis of α-acylamino-β-keto-esters: Acylation of alkyl hydrogen (acylamino)malonates via the MgCl2/R2N base system
Krysan
, p. 3303 - 3306 (1996)
An operationally simple procedure for the synthesis of α-acylamino-β-keto-esters has been devised using a MgCl2/R3N base system to generate the magnesium enolates of a series of alkyl hydrogen (acylamino)malonates. These reagents smo
Novel N→C acyl migration reaction of acyclic imides: A facile method for α-aminoketones and β-aminoalcohols
Hara, Osamu,Ito, Masao,Hamada, Yasumasa
, p. 5537 - 5540 (1998)
The acyclic imides derived from primary benzylic amines and amino acid esters easily undergo the novel N→C acyl migration reaction via a base- generated carbanion, yielding the corresponding α-aminoketones which are expedient precursors for β-aminoalcohol
An enantioselective synthesis of nitrogen protected 3-arylserine esters
Bourdon, Lisa H.,Fairfax, David J.,Martin, Gregory S.,Mathison, Casey J.,Zhichkin, Pavel
, p. 3485 - 3487 (2007/10/03)
A method for the preparation of (2R,3S) nitrogen protected arylserine esters is described. The method consists of rhodium mediated insertion of tert-butylcarbamate into the corresponding 3-keto-2-diazoester, affording the N-protected α-amino-β-ketoester, followed by asymmetric reduction/dynamic resolution to afford the corresponding N-protected 3-arylserine esters in good chemical yield, and in most cases high enantiomeric excess.
Synthesis of α-acylamino-β-oxo acid esters
Schmidt,Griesser,Lieberknecht,Schmidt,Grather
, p. 765 - 766 (2007/10/02)
α-Acylamino-β-oxo acid esters are prepared by reaction of carboxylic acid chlorides with the dilithium derivative of alkyl hydrogen (acylamino)malonate.
