151870-52-9

Basic information

• Product Name: 2-TERT-BUTOXYCARBONYLAMINO-3-OXO-3-PHENYL-PROPIONIC ACID ETHYL ESTER
• Synonyms: 2-TERT-BUTOXYCARBONYLAMINO-3-OXO-3-PHENYL-PROPIONIC ACID ETHYL ESTER;Ethyl 2-((tert-butoxycarbonyl)amino)-3-oxo-3-phenylpropanoate
• CAS NO: 151870-52-9
• Molecular Formula: C₁₆H₂₁NO₅
• Molecular Weight: 307.34
• Mol File: 151870-52-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-TERT-BUTOXYCARBONYLAMINO-3-OXO-3-PHENYL-PROPIONIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-TERT-BUTOXYCARBONYLAMINO-3-OXO-3-PHENYL-PROPIONIC ACID ETHYL ESTER(151870-52-9)
• EPA Substance Registry System: 2-TERT-BUTOXYCARBONYLAMINO-3-OXO-3-PHENYL-PROPIONIC ACID ETHYL ESTER(151870-52-9)

Safety Data

• Hazardous Substances Data: 151870-52-9(Hazardous Substances Data)

Upstream product

• 102831-44-7 diethyl tert-butoxycarbonylaminomalonate 
• 13433-00-6 diethyl aminomalonate hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 4248-19-5 tert-butyl carbazate 
• 28383-65-5 ethyl 2-diazo-3-oxo-3-phenylpropanoate 
• 98-88-4 benzoyl chloride 
• 137686-07-8 2-{[(tert-butoxy)carbonyl]amino}-3-ethoxy-3-oxopropanoic acid 

Downstream Products

• 1116503-92-4 (2S,3S)-ethyl-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-phenylpropanoate 
• 1294479-58-5 C₁₆H₂₃NO₅ 
• 350503-45-6 tert-butyl (4S,5R)-4-hydroxymethyl-2,2-dimethyl-5-phenyl-1,3-oxazolidin-3-carboxylate 
• 183075-33-4 tert-butyl (1,3-dihydroxy-1-phenylpropan-2-yl)carbamate 
• 1294479-59-6 C₁₉H₂₇NO₅ 
• 109120-55-0 (2R,3S)-phenylserine 
• 32946-42-2 (2S,3S)-2-amino-3-hydroxy-3-phenylpropanoic acid 
• 6254-48-4 (2S,3R)-3-phenylserine 
• 7352-06-9 (2R;3R)-2-amino-3-hydroxy-3-phenylpropionic acid 

Relevant articles and documents

A practical synthesis of α-acylamino-β-keto-esters: Acylation of alkyl hydrogen (acylamino)malonates via the MgCl2/R2N base system

An operationally simple procedure for the synthesis of α-acylamino-β-keto-esters has been devised using a MgCl2/R3N base system to generate the magnesium enolates of a series of alkyl hydrogen (acylamino)malonates. These reagents smo

An enantioselective synthesis of nitrogen protected 3-arylserine esters

A method for the preparation of (2R,3S) nitrogen protected arylserine esters is described. The method consists of rhodium mediated insertion of tert-butylcarbamate into the corresponding 3-keto-2-diazoester, affording the N-protected α-amino-β-ketoester, followed by asymmetric reduction/dynamic resolution to afford the corresponding N-protected 3-arylserine esters in good chemical yield, and in most cases high enantiomeric excess.