129461-28-5

Upstream product

• 41194-02-9 1-benzyl-5-hydroxypyrrolidin-2-one 
• 68-12-2 N,N-dimethyl-formamide 
• 129461-23-0 N-phenylmethyl-5-chloropyrrole-2-carboxaldehyde 
• 2142-06-5 1-(phenylmethyl)-2,5-pyrrolidinedione 

Relevant academic research and scientific papers

Metal free coupling of heteroaryl N-tosylhydrazones and thiols: Efficient synthesis of sulfides

A metal free coupling of heteroaromatic N-tosylhydrazones with thiols is presented. A convenient synthetic route to synthesize heteroaryl N-tosylhydrazones is also showed. Valuable thioethers with pyrroles, pyridines, thieno[2,3-b]pyridines, imidazo[1,2-a]pyridines, and 6H-thieno[2,3-b]pyrroles derivatives were synthesized in good yields. This coupling reaction can be carried out in a one-pot fashion and scaled up to the gram scale by using heteroaryl aldehydes, without the need to isolate the N-tosylhydrazone.

Vilsmeier-Haack reaction with succinamidals. A convenient synthesis of 5-chloropyrrole-2-carboxaldehydes and 5-chloropyrrole-2,4-dicarboxaldehydes

It is shown that the reaction of N-alkylsuccinamidals (2) with Vilsmeier-Haack reagent derived from DMF and phosphorus oxychloride can be controlled to preferentially produce either 5-chloropyrrole-2-carboxaldehydes (8) or 5-chloropyrrole-2,4-dicarboxalde