41194-02-9

Basic information

• Product Name: 2-Pyrrolidinone, 5-hydroxy-1-(phenylmethyl)-
• CAS NO: 41194-02-9
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• Mol File: 41194-02-9.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 2-Pyrrolidinone, 5-hydroxy-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrrolidinone, 5-hydroxy-1-(phenylmethyl)-(41194-02-9)
• EPA Substance Registry System: 2-Pyrrolidinone, 5-hydroxy-1-(phenylmethyl)-(41194-02-9)

Safety Data

• Hazardous Substances Data: 41194-02-9(Hazardous Substances Data)

Upstream product

• 5291-77-0 1-benzyl-2-pyrrolidone 
• 2142-06-5 1-(phenylmethyl)-2,5-pyrrolidinedione 
• 1631-26-1 1-benzyl-1H-pyrrole-2,5-dione 
• 116436-65-8 N-Benzyl-5-(phenylthio)-2-pyrrolidone 
• 100-46-9 benzylamine 
• 64984-60-7 4-oxo-4-[(phenylmethyl)amino]butanoic acid 
• 115364-11-9 5-hydroxy-N-(o-iodobenzyl)-2-pyrrolidinone 

Downstream Products

• 129461-23-0 N-phenylmethyl-5-chloropyrrole-2-carboxaldehyde 
• 129461-28-5 1-benzyl-5-chloro-1H-pyrrole-2,4-dicarbaldehyde 
• 133535-61-2 1-(phenylmethyl)-5-(phenylsulphonyl)-2-pyrrolidinone 
• 1119393-47-3 1-benzyl-5-(1H-indol-3-yl)pyrrolidin-2-one 
• 1190881-51-6 (R)-1-benzyl-5-(1H-indol-3-yl)pyrrolidin-2-one 
• 1447819-77-3 C₁₁H₁₂ClNO 
• 1285559-99-0 1-benzyl-5-(2-methyl-1H-indol-3-yl)pyrrolidin-2-one 
• 1285560-10-2 1-benzyl-5-(3-methyl-1H-indol-2-yl)pyrrolidin-2-one 
• 1119393-48-4 1-benzyl-5-(2-p-tolyl-1H-indol-3-yl)pyrrolidin-2-one 
• 1285560-13-5 1-benzyl-5-[3-(4-methyl-phenyl)indol-2-yl]pyrrolidin-2-one 
• 64330-46-7 1-benzyl-1,5-dihydro-2H-pyrrole-2-one 
• 5291-77-0 1-benzyl-2-pyrrolidone 

Relevant articles and documents

Cu(OTf)2catalyzed Ugi-type reaction ofN,O-acetals with isocyanides for the synthesis of pyrrolidinyl and piperidinyl 2-carboxamides

The Cu(OTf)2catalyzed Ugi-type reactions ofN,O-acetals with isocyanides have been described for the synthesis of pyrrolidinyl and piperidinyl 2-carboxamides. 4-Hydroxy-5-substituted-prolinamides can be obtained in high diastereoselectivities (2

Metal free coupling of heteroaryl N-tosylhydrazones and thiols: Efficient synthesis of sulfides

A metal free coupling of heteroaromatic N-tosylhydrazones with thiols is presented. A convenient synthetic route to synthesize heteroaryl N-tosylhydrazones is also showed. Valuable thioethers with pyrroles, pyridines, thieno[2,3-b]pyridines, imidazo[1,2-a]pyridines, and 6H-thieno[2,3-b]pyrroles derivatives were synthesized in good yields. This coupling reaction can be carried out in a one-pot fashion and scaled up to the gram scale by using heteroaryl aldehydes, without the need to isolate the N-tosylhydrazone.

Zinc-catalyzed selective reduction of cyclic imides with hydrosilanes: Synthesis of ω-hydroxylactams

Cyclic imides were selectively reduced to the corresponding ω-hydroxylactams in high yields with (EtO)3SiH (triethoxysilane) or PMHS (polymethylhydrosiloxane) under catalysis of zinc diacetate dehydrate [Zn(OAc)2 2H2O] (10%) and tetramethylethylenediamine (TMEDA) (10%). This catalytic protocol showed good functional group tolerance as well as excellent regioselectivity for unsymmetrical imides bearing coordinating groups adjacent to the carbonyl.