129478-11-1Relevant academic research and scientific papers
Pharmacophoric requirements for cannabinoid side chains: Multiple bond and C1'-substituted Δ8-tetrahydrocannabinols
Papahatjis,Kourouli,Abadji,Goutopoulos,Makriyannis
, p. 1195 - 1200 (2007/10/03)
Accumulated evidence indicates that within the cannabinoid structure the aliphatic side chain plays a pivotal role in determining cannabimimetic activity. We describe the synthesis and affinities for the CB1 and CB2 receptors of a series of novel Δ8
Synthesis and pharmacology of the isomeric methylheptyl-Δ8-tetrahydrocannabinols
Huffman, John W.,Liddle, John,Duncan Jr., Sammy G.,Yu, Shu,Martin, Billy R.,Wiley, Jenny L.
, p. 2383 - 2396 (2007/10/03)
The synthesis of the 3-heptyl, and the eleven isomeric 3-methylheptyl-Δ8-tetrahydrocannabinols (3-7, R and S methyl epimers, and 8) has been carried out. The synthetic approach entailed the synthesis of substituted resorcinols, which were subjected to acid catalyzed condensation with trans-para-menthadienol to provide the Δ8-THC analogue. The 1'-, 2'- and 3'-methylheptyl analogues (3-5) are considerably more potent than Δ8-THC. The 4'-, 5'- and 6'-methylheptyl isomers (6-8) are approximately equal in potency to Δ8-THC. Copyright (C) 1998 Elsevier Science Ltd.
5-Alkylresorcinols from Hakea trifurcata that cleave DNA
Lytollis, William,Scannell, Ralph T.,An, Haoyun,Murty,Reddy, K. Sambi,Barr, John R.,Hecht, Sidney M.
, p. 12683 - 12690 (2007/10/03)
A dichloromethane extract of Hakea trifurcata that mediated relaxation of ?X174 replicative form DNA at micromolar concentrations in the presence of Cu2+ was resolved into six active components by bioassay-guided fractionation. Five of the acti
