129508-07-2

Upstream product

• 121614-03-7 (1R)-N-<<(4S)-2,2-dimethyl-1,3-dioxolan-4-yl>methylene>-1-phenylethylamine N-oxide 
• 920-37-6 2-Chloroacrylonitrile 
• 118743-81-0 (R)-(+)-α-methylbenzylhydroxylamine oxalate 
• 15186-48-8 2,3-isopropylidene-glyceraldehyde 

Downstream Products

• 129508-02-7 (S)-3-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2-((R)-1-phenyl-ethyl)-isoxazolidin-5-one 
• 129508-06-1 (S)-2-((R)-1-Phenyl-ethyl)-3-((S)-2-thioxo-[1,3]dioxolan-4-yl)-isoxazolidin-5-one 
• 129508-04-9 (S)-3-((S)-1,2-Dihydroxy-ethyl)-2-((R)-1-phenyl-ethyl)-isoxazolidin-5-one 
• 129508-05-0 (4S,5S)-5-Hydroxy-4-[hydroxy-((R)-1-phenyl-ethyl)-amino]-tetrahydro-pyran-2-one 

Relevant academic research and scientific papers

SYNTHESIS OF A POTENTIAL INTERMEDIATE TO β-LACTAM ANTIBIOTICS

Cycloaddition of nitrone (2) to α-chloroacrylonitrile followed by hydrolysis afforded the isoxazolidinone (1) as a single diastereomer.The configuration at the new chiral centre (3S), corresponding to that in thienamycin, was established by an X-ray analy