SYNTHESIS OF A POTENTIAL INTERMEDIATE TO β-LACTAM ANTIBIOTICS

Article abstract of DOI:10.1016/S0040-4039(00)88835-8

Cycloaddition of nitrone (2) to α-chloroacrylonitrile followed by hydrolysis afforded the isoxazolidinone (1) as a single diastereomer.The configuration at the new chiral centre (3S), corresponding to that in thienamycin, was established by an X-ray analy