1295479-51-4

Basic information

• Product Name: C₁₈H₂₂F₂N₄O
• Synonyms: C₁₈H₂₂F₂N₄O
• CAS NO: 1295479-51-4
• Molecular Weight: 348.396
• Mol File: 1295479-51-4.mol

Chemical Properties

• CAS DataBase Reference: C₁₈H₂₂F₂N₄O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₂₂F₂N₄O(1295479-51-4)
• EPA Substance Registry System: C₁₈H₂₂F₂N₄O(1295479-51-4)

Safety Data

• Hazardous Substances Data: 1295479-51-4(Hazardous Substances Data)

Upstream product

• 86386-76-7 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole 
• 86386-77-8 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate 
• 86404-63-9 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone 
• 51336-94-8 2-chloro-1-(2,4-dichlorophenyl)ethanone 
• 372-18-9 1,3-Difluorobenzene 
• 149764-68-1 2-(2', 4'-difluorophenyl)-1-butylamino-3-(1''', 2''', 4''') triazol-1'''-yl-propan-2-ol 
• 106-96-7 propargyl bromide 

Downstream Products

• 1295479-53-6 C₂₅H₂₈F₃N₇O 
• 1295479-75-2 C₂₅H₂₇Cl₂F₂N₇O 
• 1295479-72-9 C₂₆H₂₈F₂N₈O 
• 1295479-66-1 C₂₆H₃₁F₂N₇O 
• 1295479-57-0 C₂₅H₂₈ClF₂N₇O 
• 1295479-70-7 C₂₅H₂₈F₂N₈O₃ 
• 1295479-67-2 C₂₅H₂₈F₂N₈O₃ 
• 1295479-56-9 C₂₅H₂₈ClF₂N₇O 
• 1295479-59-2 C₂₅H₂₈BrF₂N₇O 
• 1295479-68-3 C₂₅H₂₈F₂N₈O₃ 
• 1295479-60-5 C₂₅H₂₈BrF₂N₇O 
• 1295479-63-8 C₂₅H₂₈BrF₂N₇O 
• 1295479-74-1 C₂₅H₂₇Cl₂F₂N₇O 
• 1295479-52-5 C₂₅H₂₈F₃N₇O 

Relevant articles and documents

Design synthesis and biological evaluation of 3-substituted triazole derivatives

Based on the active site of lanosterol 14α-demethylase of azole antifungal agents, sixteen 1-(1H-1,2,4-triazole-1-yl)- 2-(2,4-difluorophenyl)-3- (N-n-butyl-N-1-substitutedbenzyl-4-methylene-1H-1,2,3-triazole)-2-propanols have been designed, synthesized and evaluated as antifungal agents. Results of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that some of the compounds exhibited excellent activities with broad spectrum.

Synthesis and Biological Activities of Diosgenin-Triazole Conjugates with a 1,3-Dipolar Cycloaddition Reaction

A novel series of diosgenin-triazole conjugates (10a–d, 11a–c, 12a–c, 13a–c) was designed and synthesized as antifungal agents by using a 1,3-dipolar cycloaddition reaction in the presence of a Cu(I) catalyst. All the title compounds were characterized by 1H NMR, 13C NMR, and Q-TOF-MS. Results of preliminary antifungal tests against seven human pathogenic fungi in vitro revealed that half of the target compounds exhibited moderate or even better antifungal activities against Y0109 and C. albicans SC5314 species. Compound 10d showed excellent antifungal activities toward C. albicans Y0109 and C. albicans SC5314 than itraconazole, with MIC80 value of 1 μg/mL, respectively.