129554-49-0

Upstream product

• 103319-17-1 methyl 2,4-dichloro-5-fluoro-benzoylacetate 
• 111760-50-0 2,4-dichloro-5-fluorobenzoylacetic acid 
• 704-10-9 2,4-dichloro-5-fluoroacetophenone 
• 129527-47-5 methyl-2,4-dichloro-5-fluoro-α-(4-fluoro-2-methylphenylhydrazono)benzoylacetate 

Downstream Products

• 129527-63-5 7-(3-ethylaminomethyl-1-pyrrolidinyl)-6-fluoro-1-(4-fluoro-2-methylphenyl)-1,4-dihydro-4-oxocinnoline-3-carboxylic acid 
• 129527-61-3 6-fluoro-1-(4-fluoro-2-methylphenyl)1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxocinnoline-3-carboxylic acid 
• 129527-59-9 6-fluoro-1-(4-fluoro-2-methylphenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)cinnoline-3-carboxylic acid 
• 129527-52-2 7-chloro-6-fluoro-1-(4-fluoro-2-methylphenyl)-1,4-dihydro-4-oxocinnoline-3-carboxylic acid 

Relevant academic research and scientific papers

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME 1-ARYL-1,4-DIHYDRO-4-OXOCINNOLINE-3-CARBOXYLIC ACIDS

The coupling reaction of corresponding benzene diazonium chlorides with benzoyl acetates IIIa-IIIc yielded intermediates IVa-IVe.Their intermolecular nucleophilic cyclization provided 1-aryl-1,4-dihydro-4-oxocinnoline-3-carboxylates Va-Ve.Compounds Va, Vb, Vd, and Ve were hydrolyzed to acids VIa-VIc.Treatment of these acids with the respective cyclic amines yielded compounds VIIa-VIIg which were converted to their hydrochlorides.All compounds prepared were tested for their antimicrobial activity in vitro.