methyl 7-chloro-6-fluoro-1-(4-fluoro-2-methylphenyl)-1,4-dihydro-4-oxocinnoline-3-carboxylate

Base Information

Chemical Name:methyl 7-chloro-6-fluoro-1-(4-fluoro-2-methylphenyl)-1,4-dihydro-4-oxocinnoline-3-carboxylate
CAS No.:129554-49-0
Molecular Formula:C₁₇H₁₁ClF₂N₂O₃
Molecular Weight:364.736
Hs Code.:

Synonyms:methyl 7-chloro-6-fluoro-1-(4-fluoro-2-methylphenyl)-1,4-dihydro-4-oxocinnoline-3-carboxylate

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Chemical Property of methyl 7-chloro-6-fluoro-1-(4-fluoro-2-methylphenyl)-1,4-dihydro-4-oxocinnoline-3-carboxylate

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Technology Process of methyl 7-chloro-6-fluoro-1-(4-fluoro-2-methylphenyl)-1,4-dihydro-4-oxocinnoline-3-carboxylate

There total 4 articles about methyl 7-chloro-6-fluoro-1-(4-fluoro-2-methylphenyl)-1,4-dihydro-4-oxocinnoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 129527-47-5
methyl-2,4-dichloro-5-fluoro-α-(4-fluoro-2-methylphenylhydrazono)benzoylacetate

: 129554-49-0
methyl 7-chloro-6-fluoro-1-(4-fluoro-2-methylphenyl)-1,4-dihydro-4-oxocinnoline-3-carboxylate

Guidance literature:: With 18-crown-6 ether; potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

Reference yield:

: 704-10-9
2,4-dichloro-5-fluoroacetophenone

: 129554-49-0
methyl 7-chloro-6-fluoro-1-(4-fluoro-2-methylphenyl)-1,4-dihydro-4-oxocinnoline-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: dimethylformamide / 1 h / 110 °C

2: HCl(gas) / methanol / 20 h / Ambient temperature

3: 1.) NaNO₂, aq. HCl, 2.) potassium acetate / 1.) 0 deg C, 30 min, 2.) water, methanol, dioxane, a) 5 deg C, 30 min, b) RT, 2 h

4: 91 percent / K₂CO₃, 18-crown-6 / dimethylformamide / 1 h / 100 °C

With hydrogenchloride; 18-crown-6 ether; potassium acetate; potassium carbonate; sodium nitrite; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 103319-17-1
methyl 2,4-dichloro-5-fluoro-benzoylacetate

: 129554-49-0
methyl 7-chloro-6-fluoro-1-(4-fluoro-2-methylphenyl)-1,4-dihydro-4-oxocinnoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaNO₂, aq. HCl, 2.) potassium acetate / 1.) 0 deg C, 30 min, 2.) water, methanol, dioxane, a) 5 deg C, 30 min, b) RT, 2 h

2: 91 percent / K₂CO₃, 18-crown-6 / dimethylformamide / 1 h / 100 °C

With hydrogenchloride; 18-crown-6 ether; potassium acetate; potassium carbonate; sodium nitrite; In N,N-dimethyl-formamide;