1295575-01-7

Upstream product

• 1295567-67-7 N-(3-{2-amino-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}phenyl)ethanesulfonamide 
• 1295567-66-6 N-(3-{5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-2-nitrophenoxy}phenyl)ethanesulfonamide 
• 1295567-65-5 3-(3-aminophenoxy)-5-fluoro-N-(2-fluoro-4-iodophenyl)-2-nitroaniline 
• 1295575-06-2 N-(3-{5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-2-(6-hydroxy-4,4-dioxido-4-thia-5-azaspiro[2.4]hept-5-yl)phenoxy}phenyl)ethanesulfonamide 
• 1295575-05-1 N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-1-(prop-2-en-1-yl)cyclopropanesulfonamide 
• 1295575-04-0 N-{2-(3-aminophenoxy)-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl}-1-(prop-2-en-1-yl)cyclopropanesulfonamide 
• 1295575-03-9 tert-butyl (3-{5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-2-({[1-(prop-2-en-1-yl)cyclopropyl]sulfonyl}amino)phenoxy}phenyl)carbamate 
• 1295567-72-4 tert-butyl (3-{2-amino-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}phenyl)carbamate 
• 1295567-71-3 tert-butyl (3-{5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-2-nitrophenoxy}phenyl)carbamate 
• 765962-75-2 3,5-difluoro-N-(2-fluoro-4-iodophenyl)-2-nitroaniline 
• 315-14-0 1,3,5-trifluoro-2-nitrobenzene 
• 29632-74-4 2-fluro-4-iodoaniline 

Relevant academic research and scientific papers

Modular Assembly of Allosteric MEK Inhibitor Structural Elements Unravels Potency and Feedback-Modulation Handles

Having recently identified a so-far unexplored area adjacent to the known binding site of allosteric mitogen-activated protein kinase kinase (MEK) inhibitors, we now report an extension of these studies by combining our new side chains with different MEK

SUBSTITUTED BENZOSULPHONAMIDES

The present invention relates to substituted benzosulphonamide compounds of general formula (I) : in which R1, R2, R3, R4, R5 and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations compr