1236046-48-2

Upstream product

• 1008-89-5 2-phenylpyridine 
• 933-88-0 ortho-toluoyl chloride 
• 95-47-6 o-xylene 
• 85589-35-1 o-methylmandelic acid 
• 552-45-4 1-chloromethyl-2-methylbenzene 
• 129592-98-9 2-amino-2-(o-tolyl)acetic acid 
• 1221640-33-0 N,N-dimethyl-2-(pyridin-2-yl)aniline 
• 201230-82-2 carbon monoxide 
• 91994-11-5 5,5-dimethyl-2-(o-tolyl)-1,3,2-dioxaborinane 
• 698-00-0 2-bromo-N,N-dimethylaniline 
• 529-20-4 2-methylphenyl aldehyde 
• 1404120-27-9 (2-(pyridin-2-yl)phenyl)(o-tolyl)methanol 
• 615-37-2 ortho-methylphenyl iodide 
• 98-80-6 phenylboronic acid 

Downstream Products

• 1174895-52-3 2-(2'-methyl-[1,1'-biphenyl]-2-yl)pyridine 

Relevant academic research and scientific papers

Pyridine-directed carbon–carbon single bond activation: Rhodium-catalyzed decarbonylation of aryl and heteroaromatic ketones

The decarbonylation of 2-pyridyl-substituted ketones via transition metal-catalyzed carbon–carbon bond activation provides ready access to a variety of biaryl compounds. The highly efficient and general method provides reliable decarbonylation of benzophenones including a range of functional groups and substitution patterns. The methodology has also proven highly efficient for heteroaromatic substrates, including those containing thiophenyl, indolyl, quinolinyl, and pyridine substitution.

Acylation of Arenes with Aldehydes through Dual C-H Activations by Merging Photocatalysis and Palladium Catalysis

An acylation of arenes with aldehydes through dual C-H activations at room temperature is reported. The acylation was initiated by phenanthraquinone-catalyzed hydrogen atom transfer from aldehyde under visible light irradiation. The aldehyde-derived acyl

Silver catalyzed pyridine-directed acceptorless dehydrogenation of secondary alcohols

A silver catalyzed pyridine-directed acceptorless dehydrogenation of secondary benzyl alcohols was developed. This general procedure delivers ketones with high atom-economy and hydrogen was the sole byproduct. This dehydrogenation reaction has a good functional group tolerance and high efficiency (up to 90% yield and 10,000/1 substrates-to-catalyst ratio).

A Strategy for Amide C-N Bond Activation with Ruthenium Catalyst: Selective Aromatic Acylation

A strategy for amide C-N bond activation with ruthenium catalyst is described for the first time. The in situ formed bis-cycloruthenated complexes were demonstrated to be the key active species with superior oxidative addition ability to an inert amide C-N bond. The direct C-H bond activation of 2-arylpyridines followed by the amide C-N bond activation took place in the presence of a ruthenium precatalyst to produce monoacylation products in moderate to good yields. Synthetically useful functional groups, such as halogen atoms (F and Cl), ester, acetyl, and vinyl, remained intact during tandem C-H/C-N bond activation reactions.

Preparation method of nitrogen-containing heterocyclic diarylketone compound

The invention belongs to the technical field of pharmaceutical and chemical intermediates and related chemistry, and provides a preparation method of a nitrogen-containing heterocyclic diarylketone compound. According to the method, N,N-phenyl p-toluenesulfonyl benzamide and derivatives thereof are used as acylation reagents and are subjected to a C-H acylation reaction with a 2-phenylpyridine compound in an anhydrous organic solvent under the action of a metal catalyst, a ligand, carboxylic acid and an alkali to be converted into the nitrogen-containing heterocyclic diarylketone compound. According to the preparation method of the nitrogen-containing heterocyclic diarylketone compound, reaction steps are few, amide widely existing in the nature is used as an acyl source, and the nitrogen-containing heterocyclic diarylketone compound is environmentally friendly, low in price, mild in reaction condition and convenient to operate; and the target product is obtained with high yield and high selectivity, and the method has good industrial production value and practical application value. The diarylketone compound synthesized by the method can be subjected to further functionalization reaction, and can be widely applied to the fields of synthesis of medicines, pesticides, bioactive molecules, functional material molecules and the like.

Ruthenium-Catalyzed Carbonylative Coupling of Anilines with Organoboranes by the Cleavage of Neutral Aryl C-N Bond

Herein, we report the first ruthenium-catalyzed Suzuki-type carbonylative reaction of electronically neutral anilines via C(aryl)-N bond cleavage. Without any ligand and base, diaryl ketones can be obtained in moderate to high yields by using Ru3/su

Polystyrene supported Dichloro-(8-aminoquinoline)-Palladium(II) complex catalyzed C[sbnd]H bond activation for ortho-acylation of 2-aryl pyridines

Polystyrene-supported Dichloro-(8-aminoquinoline)-Pd(II) complex C was synthesized and its catalytic efficiency was evaluated for ortho-acylation of 2-aryl pyridines with alcohols to form aryl ketones via cross dehydrogenative coupling. In addition in the presence of Pd(II) complex, toluene derivatives were also employed as an effective coupling partner for synthesis of aromatic ketones. Furthermore, this catalyst was highly stable and could be easily recovered by simple filtration and reused for four cycles with no significant decrease in its activity and selectivity.

Polystyrene-supported Pd(II) complex-catalysed carboacylation of 2-arylpyridines with alcohols via C─H bond activation under solvent-free conditions

Polystyrene-supported N,N-dimethylethylenediamine Pd(II) complex C was used as an efficient catalyst for the synthesis of aromatic ketones via ortho-acylation of sp2 C─H bonds of 2-arylpyridines with alcohols as effective coupling partners. The alcohols were oxidized with tert-butyl hydroperoxide to their corresponding aldehydes in situ and efficiently coupled with 2-arylpyridines to form aryl ketones under solvent-free conditions. Furthermore, catalyst C could be easily recovered by simple filtration and reused for five cycles without any significant decrease in its activity.

Recyclable Pd(II)complex catalyzed oxidative sp2C[sbnd]H bond acylation of 2-aryl pyridines with toluene derivatives

A recyclable polymer–anchored Pd(II) complex C was synthesized and characterized using different spectroscopic techniques. In addition the catalytic efficiency of the Pd (II) complex C was evaluated for ortho-acylation of 2-aryl pyridines with toluene derivatives to form aryl ketones via cross dehydrogenative coupling. In this catalytic process toluene acts as an effective coupling partner upon sp3C[sbnd]H bond oxidation for sp2C[sbnd]H bond acylation of 2-aryl pyridines in the presence of Pd(II)/TBHP system on water. Furthermore, the catalyst C was highly stable and could be easily recovered and reused for four cycles with no significant decrease in its activity and selectivity.

Replacing Pd(OAc)2 with supported palladium nanoparticles in ortho-directed CDC reactions of alkylbenzenes

Supported palladium nanoparticles are used as efficient catalysts for the synthesis of aromatic ketones via cross dehydrogenative coupling reactions of 2-arylpyridines with alkylbenzenes. The catalyst can be reused for five cycles without significantly losing activity. Mechanism research showed that alkylbenzenes were oxidized to their corresponding aldehydes and subsequently coupled with 2-arylpyridines to generate aryl ketones through a Pd0/PdII/PdIV catalytic cycle.