1236046-48-2

Basic information

• Product Name: (2-(pyridin-2’-yl)phenyl)(o-tolyl)methanone
• Synonyms: (2-(pyridin-2’-yl)phenyl)(o-tolyl)methanone
• CAS NO: 1236046-48-2
• Molecular Weight: 273.334
• Mol File: 1236046-48-2.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: (2-(pyridin-2’-yl)phenyl)(o-tolyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-(pyridin-2’-yl)phenyl)(o-tolyl)methanone(1236046-48-2)
• EPA Substance Registry System: (2-(pyridin-2’-yl)phenyl)(o-tolyl)methanone(1236046-48-2)

Safety Data

• Hazardous Substances Data: 1236046-48-2(Hazardous Substances Data)

Upstream product

• 1404120-27-9 (2-(pyridin-2-yl)phenyl)(o-tolyl)methanol 
• 1008-89-5 2-phenylpyridine 
• 529-20-4 2-methylphenyl aldehyde 
• 698-00-0 2-bromo-N,N-dimethylaniline 
• 1221640-33-0 N,N-dimethyl-2-(pyridin-2-yl)aniline 
• 201230-82-2 carbon monoxide 
• 91994-11-5 5,5-dimethyl-2-(o-tolyl)-1,3,2-dioxaborinane 
• 129592-98-9 2-amino-2-(o-tolyl)acetic acid 
• 552-45-4 1-chloromethyl-2-methylbenzene 
• 933-88-0 ortho-toluoyl chloride 
• 615-37-2 ortho-methylphenyl iodide 
• 95-47-6 o-xylene 
• 98-80-6 phenylboronic acid 
• 5294-03-1 di-o-tolylethyne 

Downstream Products

• 1174895-52-3 2-(2'-methyl-[1,1'-biphenyl]-2-yl)pyridine 

Relevant articles and documents

Pyridine-directed carbon–carbon single bond activation: Rhodium-catalyzed decarbonylation of aryl and heteroaromatic ketones

The decarbonylation of 2-pyridyl-substituted ketones via transition metal-catalyzed carbon–carbon bond activation provides ready access to a variety of biaryl compounds. The highly efficient and general method provides reliable decarbonylation of benzophenones including a range of functional groups and substitution patterns. The methodology has also proven highly efficient for heteroaromatic substrates, including those containing thiophenyl, indolyl, quinolinyl, and pyridine substitution.

A Strategy for Amide C-N Bond Activation with Ruthenium Catalyst: Selective Aromatic Acylation

A strategy for amide C-N bond activation with ruthenium catalyst is described for the first time. The in situ formed bis-cycloruthenated complexes were demonstrated to be the key active species with superior oxidative addition ability to an inert amide C-N bond. The direct C-H bond activation of 2-arylpyridines followed by the amide C-N bond activation took place in the presence of a ruthenium precatalyst to produce monoacylation products in moderate to good yields. Synthetically useful functional groups, such as halogen atoms (F and Cl), ester, acetyl, and vinyl, remained intact during tandem C-H/C-N bond activation reactions.

Silver catalyzed pyridine-directed acceptorless dehydrogenation of secondary alcohols

A silver catalyzed pyridine-directed acceptorless dehydrogenation of secondary benzyl alcohols was developed. This general procedure delivers ketones with high atom-economy and hydrogen was the sole byproduct. This dehydrogenation reaction has a good functional group tolerance and high efficiency (up to 90% yield and 10,000/1 substrates-to-catalyst ratio).