129593-15-3

Basic information

• Product Name: (-)-N-((S)-1-hydroxy-3-cyclohexylpropyl)benzamide
• Synonyms: (-)-N-((S)-1-hydroxy-3-cyclohexylpropyl)benzamide
• CAS NO: 129593-15-3
• Molecular Weight: 261.364
• Mol File: 129593-15-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (-)-N-((S)-1-hydroxy-3-cyclohexylpropyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-N-((S)-1-hydroxy-3-cyclohexylpropyl)benzamide(129593-15-3)
• EPA Substance Registry System: (-)-N-((S)-1-hydroxy-3-cyclohexylpropyl)benzamide(129593-15-3)

Safety Data

• Hazardous Substances Data: 129593-15-3(Hazardous Substances Data)

Upstream product

• 103322-56-1 tert-butyl [(1S)-2-cyclohexyl-1-(hydroxymethyl)ethyl]carbamate 
• 98-88-4 benzoyl chloride 
• 66605-57-0 (S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol 
• 27527-05-5 L-cyclohexylalanine 
• 131288-67-0 (2S)-2-amino-3-cyclohexyl-1-propanol 

Downstream Products

• 126832-05-1 (2S,3S)-3-amino-4-cyclohexyl-2-hydroxybutyric acid hydrochloride 
• 257296-61-0 (-)-N-((2S,3S)-3-hydroxy-1-cyclohexyl-4-pentenyl)benzamide 
• 126832-06-2 N-benzoylcyclohexylalaninal 

Relevant articles and documents

Stereoselective intramolecular cyclization of allyl and homoallyl benzamide via π-allylpalladium complex catalyzed by Pd(0)

The transformation of acyclic allylic benzamides 4 and homoallylic benzamides 12 to vinyl oxazolines 3 is achieved in the presence of base by the catalysis and Pd(0) in high yield and with high diastereoselectivity. Especially, in the case of homoallylic benzamides 12, trans-oxazolines 3 are formed exclusively or predominantly over cis-oxazolines 8, irrespective of the composition of their stereoisomers. The reaction is believed to proceed via the same π-allylpalladium complex that arises from either primary or secondary allylic acetates. We applied this method to the syntheses of β- amino-α-hydroxy acids 1 and γ-amino-β-hydroxy acids 2, conveniently protected as oxazoline.

A simple diastereoselective synthesis of cyclohexylnorstatine and allocyclohexylnorstatine

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