129604-54-2

Basic information

• Product Name: 1-(9H-FLUOREN-9-YL)PIPERAZINE
• Synonyms: AKOS BBS-00003696;1-(9H-FLUOREN-9-YL)PIPERAZINE;1-(9H-fluoren-9-yl)piperazine hydrochloride;Piperazine, 1-(9-fluorenyl)-
• CAS NO: 129604-54-2
• Molecular Formula: C₁₇H₁₈N₂
• Molecular Weight: 250.34
• Mol File: 129604-54-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 402.2°C at 760 mmHg
• Flash Point: 175.7°C
• Appearance: /
• Density: 1.161g/cm³
• Vapor Pressure: 1.11E-06mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: 1-(9H-FLUOREN-9-YL)PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(9H-FLUOREN-9-YL)PIPERAZINE(129604-54-2)
• EPA Substance Registry System: 1-(9H-FLUOREN-9-YL)PIPERAZINE(129604-54-2)

Safety Data

• Hazardous Substances Data: 129604-54-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
1-(9H-FLUOREN-9-YL)PIPERAZINE is used as a building block for the development of new pharmaceuticals due to its unique chemical structure and potential therapeutic applications.
Used in Organic Synthesis:
1-(9H-FLUOREN-9-YL)PIPERAZINE is used as a key component in organic synthesis, contributing to the creation of various complex molecules and compounds.
Used in Cancer Treatment Research:
1-(9H-FLUOREN-9-YL)PIPERAZINE is used as a potential therapeutic agent in cancer treatment research, given its promising pharmacological properties and potential to target various diseases and disorders.
Used in Neurological Condition Treatment Research:
1-(9H-FLUOREN-9-YL)PIPERAZINE is used as a potential therapeutic agent in the treatment of neurological conditions, as it has shown promise in addressing various health issues in this area.
Used in Drug Development as a Ligand:
1-(9H-FLUOREN-9-YL)PIPERAZINE is used as a potential ligand in the development of new drugs and therapeutic agents, owing to its unique chemical properties and potential for medicinal applications.

InChI:InChI=1/C17H18N2/c1-3-7-15-13(5-1)14-6-2-4-8-16(14)17(15)19-11-9-18-10-12-19/h1-8,17-18H,9-12H2

Upstream product

• 1103929-95-8 4-(9H-fluoren-9-yl)piperazin-1-carboxaldehyde 
• 1689-64-1 9-Fluorenol 
• 486-25-9 9-fluorenone 
• 110-85-0 piperazine 
• 1940-57-4 9H-fluoren-9-yl bromide 
• 6630-65-5 9-chlorofluorene 

Downstream Products

• 1103929-92-5 methyl 5-chloro-2-[({2-[4-(9H-fluoren-9-yl)piperazin-1-yl]-2-oxoethoxy}acetyl)amino]benzoate 
• 933219-06-8 (4-(9H-fluoren-9-yl)piperazin-1-yl)(4-fluorophenyl)methanone 

Relevant articles and documents

The second aryl piperazine compounds and their pharmaceutical use (by machine translation)

The invention relates to the general formula I indicated by the two aryl piperazine compound, solvate, stereoisomer or a pharmaceutically acceptable salt thereof, pharmaceutical compositions containing them, and the compounds for the preparation for preventing or treating post-surgical pain, migraine, visceral pain, neuropathic pain such as the pain and analgesics such as by analgesic drug addiction and tolerance caused by the use of disease. (by machine translation)

PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR

The present invention relates to an inhibitor of plasminogen activator inhibitor-1. The present invention further relates to a pharmaceutical composition that has an inhibitory action on PAI-1 activity and is useful in the prevention and treatment of various diseases whose onset is associated with PAI-1 activity. Furthermore, the present invention relates to a novel compound having PAI-1 inhibitory activity represented by the following general formula (I), and a salt thereof. Each symbol is defined as those in the specification.

Amino acid derivative having anti-CCK activity

A compound represented by the formula (1): STR1 wherein, m is an integer of 1 to 3; n is an integer 0 or 1; A represents CH or N atom, and forms together with the N atom bonded to the carbonyl group a piperidine ring or a piperazine ring; R1 independently represents a straight or branched chain alkyl group having 1 to 4 carbon atoms; a cycloalkyl group having 3 to 8 carbon atoms; a phenyl group, unsubstituted or substituted with a halogen atom or with an alkoxy group having 1 to 4 carbon atoms; or a pyridyl group; or two R1, together with the group >CH-- to which they bind, form a dibenzo cycloheptenyl group or a fluorenyl group; R2 represents a phenyl group substituted with a carboxyl or substituted carboxyl group; a pyridyl group substituted with a carboxyl or substituted carboxyl group, a pyrazyl group substituted with a carboxyl or substituted carboxyl group, an oxazolyl substituted with a carboxyl or substituted carboxyl group, a triazolyl substituted with one or two carboxyl or substituted carboxyl groups, or a phosphonopyridyl group; and R3 represents an indolyl group unsubstituted or substituted with a substituent selected from the group consisting of a halogen atom, a hydroxy group, an alkoxy group having 1 to 4 carbon atoms and methoxycarbonyl ethyl group and the pharmaceutically acceptable salts thereof.