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933219-06-8

(4-(9H-fluoren-9-yl)piperazin-1-yl)(4-fluorophenyl)methanone is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 933219-06-8 Structure

  • Basic information

    1. Product Name: (4-(9H-fluoren-9-yl)piperazin-1-yl)(4-fluorophenyl)methanone
    2. Synonyms: (4-(9H-fluoren-9-yl)piperazin-1-yl)(4-fluorophenyl)methanone
    3. CAS NO:933219-06-8
    4. Molecular Formula:
    5. Molecular Weight: 372.442
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 933219-06-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (4-(9H-fluoren-9-yl)piperazin-1-yl)(4-fluorophenyl)methanone(CAS DataBase Reference)
    10. NIST Chemistry Reference: (4-(9H-fluoren-9-yl)piperazin-1-yl)(4-fluorophenyl)methanone(933219-06-8)
    11. EPA Substance Registry System: (4-(9H-fluoren-9-yl)piperazin-1-yl)(4-fluorophenyl)methanone(933219-06-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 933219-06-8(Hazardous Substances Data)

933219-06-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 933219-06-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,3,3,2,1 and 9 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 933219-06:
(8*9)+(7*3)+(6*3)+(5*2)+(4*1)+(3*9)+(2*0)+(1*6)=158
158 % 10 = 8
So 933219-06-8 is a valid CAS Registry Number.

933219-06-8Downstream Products

933219-06-8Relevant articles and documents

Piperazine derivatives: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase and SAR studies

Rotta, Mariane,Pissinate, Kenia,Villela, Anne Drumond,Back, Davi Fernando,Timmers, Luis Fernando Saraiva Macedo,Bachega, José Fernando Ruggiero,De Souza, Osmar Norberto,Santos, Diógenes Santiago,Basso, Luiz Augusto,Machado, Pablo

, p. 436 - 447 (2015)

The Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA) catalyzes hydride transfer to long-chain enoyl thioester substrates. MtInhA is a member of the mycobacterial type II dissociated fatty acid biosynthesis system, and is the bona fide target for isoniazid, the most prescribed drug for tuberculosis treatment. Here, a series of piperazine derivatives was synthesized and screened as MtInhA inhibitors, which resulted in the identification of compounds with IC50 values in the submicromolar range. A structure-activity relationship (SAR) evaluation indicated the importance of the chemical environment surrounding the carbonyl group for inhibition. In addition, the structure of one selected compound was supported by crystallographic studies, and experimental geometrical values were compared with semi-empirical quantum chemical calculations. Furthermore, the mode of inhibition and inhibitory dissociation constants were determined for the nine most active compounds. These findings suggest that these 9H-fluoren-9-yl-piperazine-containing compounds interact with MtInhA at the enoyl thioester (2-trans-dodecenoyl-CoA) substrate binding site.

Piperazine derivatives: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase and SAR studies

Rotta, Mariane,Pissinate, Kenia,Villela, Anne Drumond,Back, Davi Fernando,Timmers, Luis Fernando Saraiva MacEdo,Bachega, Jos Fernando Ruggiero,De Souza, Osmar Norberto,Santos, Digenes Santiago,Basso, Luiz Augusto,MacHado, Pablo

, p. 436 - 447 (2015/08/19)

The Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA) catalyzes hydride transfer to long-chain enoyl thioester substrates. MtInhA is a member of the mycobacterial type II dissociated fatty acid biosynthesis system, and is the bona fide target for isoniazid, the most prescribed drug for tuberculosis treatment. Here, a series of piperazine derivatives was synthesized and screened as MtInhA inhibitors, which resulted in the identification of compounds with IC50 values in the submicromolar range. A structure-activity relationship (SAR) evaluation indicated the importance of the chemical environment surrounding the carbonyl group for inhibition. In addition, the structure of one selected compound was supported by crystallographic studies, and experimental geometrical values were compared with semi-empirical quantum chemical calculations. Furthermore, the mode of inhibition and inhibitory dissociation constants were determined for the nine most active compounds. These findings suggest that these 9H-fluoren-9-yl-piperazine-containing compounds interact with MtInhA at the enoyl thioester (2-trans-dodecenoyl-CoA) substrate binding site.

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