129608-85-1Relevant academic research and scientific papers
Catalytic Asymmetric Synthesis of N-Chiral Amine Oxides
Bhadra, Sukalyan,Yamamoto, Hisashi
supporting information, p. 13043 - 13046 (2016/10/30)
Direct asymmetric synthesis of N-chiral amine oxides was accomplished (up to 91:9 e.r.) by means of a bimetallic titanium catalyst. A hydroxy group situated at the γ-position of the N stereocenter enables the desired N-oxidation through dynamic kinetic resolution of the trivalent amine substrates. The method was further extended to the kinetic resolution of racemic γ-amino alcohols with a preexisting stereocenter, giving an important class of enantioenriched (up to 99.9:0.1 e.r.) building blocks that are otherwise difficult to synthesize.
AN EFFICIENT SYNTHESIS OF 3-tert-AMINOPROPANOL DERIVATIVES BY REGIOSELECTIVE RING OPENING OF TETRAHYDRO-1,3-OXAZINES WITH GRIGNARD REAGENTS
Alberola, Angel,Alvarez, Maria A.,Andres, Celia,Gonzalez, Alfonso,Pedrosa, Rafael
, p. 1149 - 1158 (2007/10/02)
N-Benzyl tetrahydro-1,3-oxazines react with methylmagnesium iodide, benzylmagnesium bromide, allylmagnesium chloride and phenylmagnesium bromide affording 3-tert-aminopropanol derivatives with excellent yields.By contrast, the same substrates do no react
