1296160-84-3Relevant academic research and scientific papers
Glycoconjugates, products of uridine derivatives phosphitylation and oxidation as glycosyltransferases potential inhibitors
Grec, Marta,Swierk, Piotr,Pastuch, Gabriela,Szeja, Wieslaw
experimental part, p. 652 - 663 (2011/06/19)
The title compounds, variously protected 5′-uridine derivatives connected with 1-thiosugar with thiophosphoesters fragment (17-22) were synthesized in sequence of reactions: phosphitylation - reaction of 5′-hydroxyl group of selectively protected nucleoside with a phosphitylating agent (N,N-diisopropyl chlorophosphoamidite), connection an phosphoroamidites with 2-bromoethanol or 3-bromopropanol and secondary oxidation with sulfur presence and finally condensation reaction of obtained products with 1-thiosugar. Received glycoconjugates (17-22) had a structure which mimic to structure of natural glycosyltransferases substrates.
