129649-57-6Relevant academic research and scientific papers
Gold-catalyzed construction of two adjacent quaternary stereocenters via sequential C-H functionalization and aldol annulation
Yu, Zhunzhun,Qiu, Haile,Liu, Lu,Zhang, Junliang
supporting information, p. 2257 - 2260 (2016/02/12)
Herein, a novel and efficient gold-catalyzed intermolecular C(sp2)-H functionalization (Friedel-Crafts alkylation) and aldol annulation strategy is presented. This cascade process allows the synthesis of a series of indanol and tetrahydronaphthalenol derivatives with two adjacent quaternary stereocenters. The attractive reaction features are the use of readily available starting materials, good diastereoselectivity, good functional-group tolerance and mild reaction conditions. Furthermore, preliminary results indicate that this transformation is amenable to enantioselectivitive synthesis with further chiral ligand screening and design.
The development of a novel series of (quinolin-2-ylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 3. Structural variation of the acidic side chain to give antagonists of enhanced potency
Galemmo Jr.,Johnson Jr.,Learn,Lee,Huang,Campbell,Youssefyeh,O'Rourke,Schuessler,Sweeney,Travis,Sutherland,Nuss,Carnathan,Van Inwegen
, p. 2828 - 2841 (2007/10/02)
This paper is the third in a series outlining the development of orally active sulfido peptide leukotriene antagonists containing a (quinolin-2-ylmethoxy)phenyl moiety. In this work the systematic variation of the acid side chain substituents led to drama
