1296783-87-3Relevant academic research and scientific papers
Green synthetic investigation and spectral characterization of some spiro pyrazolidine-based heterocycles with potential biological activity
El-Ossaily, Yasser A.,Metwally, Saoud A.,Al-Muailkel, Nayef S.,Fawzy, Ahmed,Ali, Hazim M.,Naffea, Yousra A.
, p. 1729 - 1736 (2020/01/25)
A green, rapid, and efficient methodology is developed for the synthesis of 1-phenyl-3,5-pyrazolidinedione (3) by the reaction of malonic acid with phenyl hydrazine in the presence of phosphorous oxychloride under solvent-free conditions. The later compou
Novel synthesis of highly functionalized pyrazolone systems via rearrangement of 5-phenyl-1-oxa-5,6-diazaspiro[2.4]heptane-4,7-diones
Metwally,Mohamed,Moustafa,El-Ossaily
experimental part, p. 1344 - 1353 (2011/10/17)
Epoxidation of 4-alkylidene(arylidene)-1-phenyl-3,5-pyrazolidinediones using alkaline hydrogen peroxide gave the corresponding 5-phenyl-1-oxa-5,6- diazaspiro[2.4]heptane-4,7-dione derivatives. Their reaction with nucleophilic reagents was investigated. The resulting products depend on the type of the diazaspiro compound and/or the nucleophile used.
