129679-71-6

Upstream product

• 57956-47-5 ethyl 3-((tert-butyldimethylsilyl)oxy)-3-phenylpropanoate 
• 100-52-7 benzaldehyde 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 340165-30-2 4-(tert-butyldimethylsilyloxy)-4-phenylbut-1-ene 
• 129634-33-9 3-(tert-Butyl-dimethyl-silanyloxy)-3-phenyl-thiopropionic acid S-ethyl ester 

Downstream Products

• 1428990-73-1 C₁₇H₂₅NOSi 
• 1428990-74-2 C₁₇H₂₅NOSi 
• 104-55-2 3-phenyl-propenal 
• 948050-78-0 1-(tert-butyldimethylsilyloxy)-1-phenylhex-5-en-3-ol 

Relevant academic research and scientific papers

BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF

The invention provides novel compounds having the general formula (I): (I) wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.

BICYCLIC COMPOUNDS FOR USE AS RIP1 KINASE INHIBITORS

The invention provides novel compounds having the general formula (I) or pharmaceutically acceptable salts thereof, wherein RA, RB1, RB2, the A ring and the B ring are as described herein, pharmaceutical compositions inclu

N-[4-OXO-2,3-DIHYDRO-1,5-BENZOXAZEPIN-3-YL]-5,6-DIHYDRO-4H-PYRROLO[1,2-B]PYRAZOL E-2-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS RIP1 KINASE INHIBITORS FOR TREATING E.G. IRRITABLE BOWEL SYNDROME (IBS)

The invention provides compounds having the general formula (I): or pharmaceutically acceptable salts thereof, wherein X, Y, R1, R2, R7a, R7b, X, RB1, RB2, n, p, q, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and the compounds for use as receptor-interacting protein-1 (RIP1) kinase inhibitors in methods of treating e.g. Parkinson's or Alzheimer's disease, irritable bowel disorders (IBD), Crohn's disease, respiratory distress syndrome (ARDS) or chronic obstructive pulmonary disease (COPD). An exemplary compound is e.g. (4S,6S)-4-fluoro-6-phenyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-l,5- benzoxazepin-3-yl]-5,6-dihydro-4H-pyrrolo[l,2-b]pyrazole-2- carboxamide (example 11) with a Ki (uM) in a RIP1 assay of 0.0044 uM..

Expeditious syntheses of (±)-allo-sedamine and (±)-allo- lobeline via a combination of aza-Sakurai-Hosomi and hydroformylation reactions

The expeditious preparation of allo-sedamine and allo-lobeline via 1,3-diastereoselective aza-Sakurai-Hosomi reaction followed by hydroformylation is reported. Georg Thieme Verlag Stuttgart.

Total synthesis of (+/-)-diospongin A via Prins reaction

A straightforward synthesis of (+/-)-diospongin A starting from benzaldehyde is described. A Prins cyclization reaction to control the relative configuration of the three stereogenic centers and a Mitsunobu inversion represent the key steps of the approac

Reduction of ethanethiol esters to aldehydes

Reduction of ethanethiol esters of α-amino acids to α-amino aldehydes by triethylsilane and catalytic palladium-on-carbon is described. α-Amino aldehydes with Boc, Cbz, or Fmoc protection could be obtained without racemization in high yield.

Z-selective Horner-Wadsworth-Emmons reaction of (α-substituted ethyl (Diarylphosphono)acetates with aldehydes

New Horner-Wadsworth-Emmons reagents, ethyl 2- (diarylphosphono)propionates (2), ethyl 2-(diarylphosphono)hexanoates (3), and ethyl 2-(diarylphosphono)-3-methylbutanoates (4) were prepared by alkylation of ethyl (diarylphosphono)acetates. The reaction of

Highly Selective Synthesis of Z-Unsaturated Esters by Using New Horner-Emmons Reagents, Ethyl (Diarylphosphono)acetates

New Horner-Emmons reagents, ethyl (diarylphosphono)acetates 1, were prepared from triethyl phosphonoacetate, PCl5 the corresponding phenols. The reaction of 1 with several kinds of aldehydes in the presence of Triton B or NaH in THF solvent revealed that these reagents are useful for the synthesis of Z-unsaturated esters. Among the reagents examined, ethyl(di-o-tolylphosphono)-, [bis(o-ethylphenyl)phosphonol-, and [bis(o-isopropylphenyl)phosphono]acetates (1k-m) were found to be the most effective, giving Z-unsaturated esters with 93-99% selectivity.