129686-06-2Relevant articles and documents
Preparation of carboranyl porphyrins for boron neutron capture therapy
Miura, Michiko,Gabel, Detlef,Oenbrink, Georg,Fairchild, Ralph G.
, p. 2247 - 2250 (1990)
The preparation of two structurally different boronated porphyrins is described for use in Boron Neutron Capture Therapy. One is a derivative of a natural porphyrin and the other is a derivative of tetraphenylporphyrin.
PROCESS FOR THE PREPARATION OF A SUBSTITUTED PORPHYRIN
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Page/Page column 20-21, (2010/11/08)
Processes are disclosed for the preparation of a compound having the formula: (I) and intermediate compounds wherein M is a single-photon-emission tomography imageable radiometal and/or a paramagnetic metal, R is hydrogen or a halogen provided that at least one R is halogen and Y is selected from ortho, meta or para O(CH2)nC2HB9H10 or O(CH2)nC2HB 10H10 wherein n is 0 or an integer from 1 to 20 and O(CH2)nC2HB9H10 is nido ortho-, meta- or para- carborane and O(CH2)nC2HB10H10 is ortho-, meta- or para-carborane.
DNA binding compounds. VII synthesis, characterization and DNA binding capacity of 1,2-dicarba-closo-dodecaborane bibenzimidazoles related to the DNA minor groove binder Hoechst 33258
Bateman, Stuart A.,Kelly, David P.,Martin, Roger F.,White, Jonathan M.
, p. 291 - 301 (2007/10/03)
A series of bibenzimidazole derivatives based on the known DNA minor groove binder Hoechst 33258 have been prepared to include a 1,2-dicarba-closo-dodecaborane cage for potential use in boron neutron capture therapy (BNCT). The carborane derivatives (5)-(7) were chosen to reduce the steric inhibition of minor groove DNA binding displayed by the previously prepared carborane ligand (4). The synthesis and preliminary DNA binding studies of these bibenzimidazole derivatives are presented herein.