34905-03-8Relevant articles and documents
PROCESS FOR THE PREPARATION OF A SUBSTITUTED PORPHYRIN
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Page/Page column 20, (2010/11/08)
Processes are disclosed for the preparation of a compound having the formula: (I) and intermediate compounds wherein M is a single-photon-emission tomography imageable radiometal and/or a paramagnetic metal, R is hydrogen or a halogen provided that at least one R is halogen and Y is selected from ortho, meta or para O(CH2)nC2HB9H10 or O(CH2)nC2HB 10H10 wherein n is 0 or an integer from 1 to 20 and O(CH2)nC2HB9H10 is nido ortho-, meta- or para- carborane and O(CH2)nC2HB10H10 is ortho-, meta- or para-carborane.
DNA binding compounds. VII synthesis, characterization and DNA binding capacity of 1,2-dicarba-closo-dodecaborane bibenzimidazoles related to the DNA minor groove binder Hoechst 33258
Bateman, Stuart A.,Kelly, David P.,Martin, Roger F.,White, Jonathan M.
, p. 291 - 301 (2007/10/03)
A series of bibenzimidazole derivatives based on the known DNA minor groove binder Hoechst 33258 have been prepared to include a 1,2-dicarba-closo-dodecaborane cage for potential use in boron neutron capture therapy (BNCT). The carborane derivatives (5)-(7) were chosen to reduce the steric inhibition of minor groove DNA binding displayed by the previously prepared carborane ligand (4). The synthesis and preliminary DNA binding studies of these bibenzimidazole derivatives are presented herein.
Selective upper rim functionalization and lower rim bridge building with calix[4]arenes and calix[6]arenes
Kanamathareddy, Suseela,Gutsche, C. David
, p. 2511 - 2516 (2007/10/03)
Selective upper rim functionalization of calix[6]arenes has been achieved by selective lower rim benzoylation at the 1,2,4,5 positions followed by AlCl3-induced removal of the tert-butyl groups of the unesterified aryl residues and introduction of various functionalities into the vacated para positions, including bromo (5), dialkylamino, (7-11) cyanomethyl (12), and (propargyloxy)methyl (13) groups. Lower rim bridge building has been achieved via oxidative coupling reactions between the aryne moieties of calix[4]arenes and calix[6]arenes in which O-benzyl groups carry one (from 23 and 24) or two (from 25) propargyloxy residues. In the calix[4]arene series both a single-spanned (32) and a double-spanned (33) double-cavity calixarene were obtained. In the calix[6]arene series only a single-spanned double cavity calixarene (36) could be characterized.
Preparation of carboranyl porphyrins for boron neutron capture therapy
Miura, Michiko,Gabel, Detlef,Oenbrink, Georg,Fairchild, Ralph G.
, p. 2247 - 2250 (2007/10/02)
The preparation of two structurally different boronated porphyrins is described for use in Boron Neutron Capture Therapy. One is a derivative of a natural porphyrin and the other is a derivative of tetraphenylporphyrin.
