129688-97-7Relevant academic research and scientific papers
N-substituted spirosuccinimide, spiropyridazine, spiroazetidine, and acetic acid aldose reductase inhibitors derived from isoquinoline-1,3- diones. 2
Malamas,Hohman
, p. 2059 - 2070 (2007/10/02)
The isoquinoline-1,3-dione framework featured in our clinical candidate (1) and its congener was used as the template in the design of several new series of aldose reductase inhibitors (ARIs). These series included N'- substituted spirosuccinimide, spirop
PROCESS AND INTERMEDIATES FOR THE PREPARATION OF SPIRO(ISOQUINOLINE-4(1H), 3'-PYRROLIDINE)-1,2',3,5'(2H)-TETRONES WHICH ARE USEFUL AS ALDOSE REDUCTASE INHIBITORS
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, (2008/06/13)
The invention relates to a process for producing spiroisoquinoline pyrrolidines. The compounds have pharmaceutical properties which render them beneficial for the prevention or treatment of diabetes mellitus associated complications.
ISOQUINOLINE ACETIC ACIDS AND ACETYL CARBAMATES USEFUL AS ALDOSE REDUCTASE INHIBITORS
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, (2008/06/13)
This invention relates to isoquinoline acetic acids and acetyl carbamates and their pharmaceutically acceptable salts thereof, to processes for their preparation, to methods for using the compounds, and to pharmaceutical preparations thereof. The compounds have pharmaceutical properties which render them beneficial for thetreatment of diabetes mellitus and associated conditions
SPIRO-ISOQUINOLINE-PYRROLIDINE TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS
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, (2008/06/13)
This invention relates to spiro-isoquinoline-pyrrolidine tetrones and their pharmaceutically acceptable salts thereof, to processes for their preparation, to methods for using the compounds, and to pharmaceutical preparations thereof. The compounds have pharmaceutical properties which render them beneficial for the prevention of diabetes mellitus associated complications
