129694-47-9Relevant academic research and scientific papers
Enantioselective total synthesis of (+)-isoaltholactone
Peng, Xiaoshui,Li, Anpai,Lu, Jiangping,Wang, Qiaoling,Pan, Xinfu,Chan, Albert S.C
, p. 6799 - 6804 (2007/10/03)
A facile enantioselective route to highly functionalized α,β-unsaturated -δ-lactones has allowed for the synthesis of (+)-isoaltholactone in 6.4% overall yield from furylmethanol. This approach derived its asymmetry by applying Sharpless kinetic resolution on racemic 2-furylmethanol. The resulting pyranone was produced in high enantioexcess and was stereoselectively transformed into (+)-isoaltholactone via a highly diastereoselective epoxidation and a key PPTS catalyzed intramolecular cyclization.
Enantioselective Syntheses of (+)-Acetylphomalactone and (6R)-(+)-Goniothalamin from 2-Furylmethanols
Honda, Toshio,Kametani, Tetsuji,Kanai, Kazuo,Tatsuzaki, Yoko,Tsubuki, Masayoshi
, p. 1733 - 1737 (2007/10/02)
Enantioselective syntheses of two 6-substituted 5,6-dihydro-2H-pyran-2-ones, (+)-acetylphomalactone and (6R)-(+)-goniothalamin, are described which use the kinetic resolution of racemic secondary 2-furylmethanols.
