474126-22-2Relevant academic research and scientific papers
Enantioselective total synthesis of (+)-isoaltholactone
Peng, Xiaoshui,Li, Anpai,Lu, Jiangping,Wang, Qiaoling,Pan, Xinfu,Chan, Albert S.C
, p. 6799 - 6804 (2007/10/03)
A facile enantioselective route to highly functionalized α,β-unsaturated -δ-lactones has allowed for the synthesis of (+)-isoaltholactone in 6.4% overall yield from furylmethanol. This approach derived its asymmetry by applying Sharpless kinetic resolution on racemic 2-furylmethanol. The resulting pyranone was produced in high enantioexcess and was stereoselectively transformed into (+)-isoaltholactone via a highly diastereoselective epoxidation and a key PPTS catalyzed intramolecular cyclization.
