129696-75-9

Basic information

• Product Name: 4-Fluoro-benzoic acid 6-acetyl-2-cyano-3,4-dimethyl-phenyl ester
• Synonyms: 4-Fluoro-benzoic acid 6-acetyl-2-cyano-3,4-dimethyl-phenyl ester
• CAS NO: 129696-75-9
• Molecular Weight: 311.312
• Mol File: 129696-75-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-Fluoro-benzoic acid 6-acetyl-2-cyano-3,4-dimethyl-phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-benzoic acid 6-acetyl-2-cyano-3,4-dimethyl-phenyl ester(129696-75-9)
• EPA Substance Registry System: 4-Fluoro-benzoic acid 6-acetyl-2-cyano-3,4-dimethyl-phenyl ester(129696-75-9)

Safety Data

• Hazardous Substances Data: 129696-75-9(Hazardous Substances Data)

Upstream product

• 89638-56-2 3-cyano-4,5-dimethyl-2-hydroxyacetophenone 
• 403-43-0 4-fluorobenzoyl chloride 

Downstream Products

• 1400815-96-4 methyl 2-(4-fluorophenyl)-6,7-dimethyl-4-oxo-4H-chromene-8-carboxylate 
• 129696-98-6 2-(4-Fluoro-phenyl)-6,7-dimethyl-4-oxo-4H-chromene-8-carboxylic acid 
• 129697-09-2 2-(4-Fluoro-phenyl)-6,7-dimethyl-4-oxo-4H-chromene-8-carbonitrile 
• 129696-86-2 3-[3-(4-Fluoro-phenyl)-3-oxo-propionyl]-2-hydroxy-5,6-dimethyl-benzonitrile 

Relevant articles and documents

Cell death triggered by synthetic flavonoids in human leukemia cells is amplified by the inhibition of extracellular signal-regulated kinase signaling

A new class of methyl esters of flavonoids, with different substituents on the B ring were synthesized and evaluated for their antiproliferative activity against the human leukemia cell line HL-60. The presence of either a methyl group (1f) or a chlorine atom (1o) at position 2′ of the B ring played an important role in affecting antiproliferative activity. The cytotoxic effects of these compounds were accompanied by the concentration- and time-dependent appearance of DNA- and nuclear-fragmentation, increase in the percentage of sub-G1 cells, and processing of multiple caspases and poly(ADP-ribose)polymerase cleavage. Pretreatment of cells with the specific mitogen-activated extracellular kinases (MEK) 1/2 inhibitor PD98059, together with 1f and 1o, resulted in an important enhancement of cell death, which might have clinical implications for the use of both compounds in combination with MEK 1/2 inhibitors as potential therapeutic agents.