129696-75-9

Upstream product

• 89638-56-2 3-cyano-4,5-dimethyl-2-hydroxyacetophenone 
• 403-43-0 4-fluorobenzoyl chloride 

Downstream Products

• 1400815-96-4 methyl 2-(4-fluorophenyl)-6,7-dimethyl-4-oxo-4H-chromene-8-carboxylate 
• 129696-98-6 2-(4-Fluoro-phenyl)-6,7-dimethyl-4-oxo-4H-chromene-8-carboxylic acid 
• 129697-09-2 2-(4-Fluoro-phenyl)-6,7-dimethyl-4-oxo-4H-chromene-8-carbonitrile 
• 129696-86-2 3-[3-(4-Fluoro-phenyl)-3-oxo-propionyl]-2-hydroxy-5,6-dimethyl-benzonitrile 

Relevant academic research and scientific papers

Cell death triggered by synthetic flavonoids in human leukemia cells is amplified by the inhibition of extracellular signal-regulated kinase signaling

A new class of methyl esters of flavonoids, with different substituents on the B ring were synthesized and evaluated for their antiproliferative activity against the human leukemia cell line HL-60. The presence of either a methyl group (1f) or a chlorine atom (1o) at position 2′ of the B ring played an important role in affecting antiproliferative activity. The cytotoxic effects of these compounds were accompanied by the concentration- and time-dependent appearance of DNA- and nuclear-fragmentation, increase in the percentage of sub-G1 cells, and processing of multiple caspases and poly(ADP-ribose)polymerase cleavage. Pretreatment of cells with the specific mitogen-activated extracellular kinases (MEK) 1/2 inhibitor PD98059, together with 1f and 1o, resulted in an important enhancement of cell death, which might have clinical implications for the use of both compounds in combination with MEK 1/2 inhibitors as potential therapeutic agents.

FURAN o-AMINONITRILES AS PRECURSORS TO FLAVONE ANALOGUES

A procedure utilizing furan o-aminonitriles as precursors in the synthesis of substituted flavone analogues is reported.The key intermediates, o-hydroxyacetophenones, are obtained by a Diels-Alder reaction between the furans and methyl vinyl ketone.