129758-83-4

Upstream product

• 10508-57-3 3-bromo-1-phenyl-prop-2-yn-1-ol 
• 108-24-7 acetic anhydride 
• 16169-88-3 1-phenylprop-2-ynyl acetate 

Downstream Products

• 69798-68-1 3-bromo-2-oxo-1-phenylpropyl acetate 
• 1579278-75-3 3-bromo-2-oxo-1-phenylpropyl acetate 
• 1579278-76-4 3-bromo-1-hydroxy-1-phenylpropan-2-one 

Relevant academic research and scientific papers

Trialkylborane-Mediated Multicomponent Reaction for the Diastereoselective Synthesis of Anti-δ,δ-Disubstituted Homoallylic Alcohols

The trialkylborane/O2-mediated reaction of propargyl acetates having a tributylstannyl group at an alkyne terminus with aldehydes in a THF-H2O solvent system gave anti-δ,δ-disubstituted homoallylic alcohols with good to high diastereoselectivity. Intriguingly, two alkyl groups derived from trialkylborane were embedded into the reaction product. The trialkylborane plays a key role not only as a radical initiator but also as a source of alkyl radicals.

Regioselective hydration of terminal halo-substituted propargyl carboxylates by gold catalyst: Synthesis of α-acyloxy α'-halo ketones

Regioselective hydration of the terminal halo-substituted propargyl carboxylate by gold(I) catalyst is reported. The mild catalytic conditions tolerate common acid-labile protecting groups, and a wide variety of α-acyloxy α'-halo ketones are efficiently synthesized within a short reaction time. The α-acyloxy α'-halo ketones are used for the synthesis of 2-aminothiazoles.

Convenient preparation of bromoalkynes from primary alkynes and PPh3/CBr4

1-Bromo-1-alkynes are prepared in high yields under very mild conditions by treatment of primary alkynes with PPh3/CBr4.