1297655-06-1

Basic information

• Product Name: 4-(3,5-bis((E)-4-Hydroxy-3-Methoxystyryl)-1H-pyrazol-1-yl)benzoic acid
• Synonyms: 4-(3,5-bis((E)-4-Hydroxy-3-Methoxystyryl)-1H-pyrazol-1-yl)benzoic acid
• CAS NO: 1297655-06-1
• Molecular Formula: C28H24N2O6
• Molecular Weight: 484.49996
• Mol File: 1297655-06-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(3,5-bis((E)-4-Hydroxy-3-Methoxystyryl)-1H-pyrazol-1-yl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3,5-bis((E)-4-Hydroxy-3-Methoxystyryl)-1H-pyrazol-1-yl)benzoic acid(1297655-06-1)
• EPA Substance Registry System: 4-(3,5-bis((E)-4-Hydroxy-3-Methoxystyryl)-1H-pyrazol-1-yl)benzoic acid(1297655-06-1)

Safety Data

• Hazardous Substances Data: 1297655-06-1(Hazardous Substances Data)

Upstream product

• 458-37-7 curcumin 
• 123-54-6 acetylacetone 
• 121-33-5 vanillin 
• 458-37-7 curcumin 
• 619-67-0 4-Hydrazinobenzoic acid 

Relevant articles and documents

Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation

Curcumin and some of its derivatives were known as in vivo inhibitors of angiogenesis. In present study, a novel curcumin derivative, named hydrazinocurcumin (HC) was synthesized and examined for its biological activities. HC potently inhibited the proliferation of bovine aortic endothelial cells (BAECs) at a nanomolar concentration (IC50=520 nM) without cytotoxicity. In vivo and in vitro angiogenesis experiments showed HC as a new candidate for anti-angiogenic agent.

New histone deacetylase inhibitors and anticancer agents from Curcuma longa

The aims of this study were to explore histone deacetylase inhibitory and antioxidant activities of curcuminoids as well as derivatives of curcumin. Curcumin (6), demethoxycurcumin (7), dihydrocurcumin (8), bisdemethoxycurcumin (9), and hydroxycurcumin (1

NOVEL CURCUMIN DERIVATIVES

The present invention relates to a novel curcumin derivative and a pharmaceutical composition, in particular to a novel curcumin derivative with anti-angiogenic activity and a pharmaceutical composition for treating or preventing a disease associated with unregulated angiogenesis.