1297655-06-1Relevant academic research and scientific papers
Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation
Shim, Joong Sup,Kim, Dong Hoon,Jung, Hye Jin,Kim, Jin Hee,Lim, Dongyeol,Lee, Seok-Ki,Kim, Kyu-Won,Ahn, Jong Woong,Yoo, Jong-Shin,Rho, Jung-Rae,Shin, Jongheon,Kwon, Ho Jeong
, p. 2987 - 2992 (2002)
Curcumin and some of its derivatives were known as in vivo inhibitors of angiogenesis. In present study, a novel curcumin derivative, named hydrazinocurcumin (HC) was synthesized and examined for its biological activities. HC potently inhibited the proliferation of bovine aortic endothelial cells (BAECs) at a nanomolar concentration (IC50=520 nM) without cytotoxicity. In vivo and in vitro angiogenesis experiments showed HC as a new candidate for anti-angiogenic agent.
Hydrazinocurcumin, a novel synthetic curcumin derivative, Is a potent inhibitor of endothelial cell proliferation
Sup Shim, Joong,Hoon Kim, Dong,Jung, Hye Jin,Hee Kim, Jin,Lim, Dongyeol,Lee, Seok-Ki,Kim, Kyu-Won,Ahn, Jong Woong,Yoo, Jong-Shin,Rho, Jung-Rae,Shin, Jongheon,Jeong Kwon, Ho
, p. 2439 - 2444 (2002)
Curcumin and some of its derivatives were known as in vivo inhibitors of angiogenesis. In present study, a novel curcumin derivative, named hydrazinocurcumin (HC) was synthesized and examined for its biological activities. HC potently inhibited the proliferation of bovine aortic endothelial cells (BAECs) at a nanomolar concentration (IC50=520 nM) without cytotoxicity. In vivo and in vitro angiogenesis experiments showed HC as a new candidate for anti-angiogenic agent. 2002 Elsevier Science. All rights reserved.
New histone deacetylase inhibitors and anticancer agents from Curcuma longa
Kumboonma, Pakit,Senawong, Thanaset,Saenglee, Somprasong,Senawong, Gulsiri,Somsakeesit, La-or,Yenjai, Chavi,Phaosiri, Chanokbhorn
, p. 1773 - 1782 (2019/08/08)
The aims of this study were to explore histone deacetylase inhibitory and antioxidant activities of curcuminoids as well as derivatives of curcumin. Curcumin (6), demethoxycurcumin (7), dihydrocurcumin (8), bisdemethoxycurcumin (9), and hydroxycurcumin (1
Mechanochemical Synthesis and Antioxidant Activity of Curcumin-Templated Azoles
Sherin, Daisy R.,Rajasekharan, Kallikat N.
, p. 908 - 914 (2015/12/24)
A solvent-free, mechanochemical method for the synthesis of curcumin (1) derived 3,5-bis(styryl)pyrazoles and 3,5-bis(styryl)isoxazole (2a-g) at room temperature, with very short reaction time, is reported. Such earlier structural modifications of curcumin, at its β-diketone unit by transforming it into an isosteric pyrazole or isoxazole unit, required prolonged heating. The evaluation of the antioxidant activity of these compounds, based on DPPH, FRAP, and β-carotene bleaching assays, showed that several of these azoles are better antioxidants than curcumin, with the isoxazole derivative 2g being overall the best. Typically, the inhibition of 2,2-diphenyl-1-picrylhydrazyl (10-2 mmol), expressed as EC50 values, by curcumin (1), 3,5-bis(4-hydroxy-3-methoxystyryl)pyrazole (2a), and 3,5-bis(4-hydroxy-3-methoxystyryl)isoxazole (2g) are 40 ± 0.06, 14 ± 0.18, and 8 ± 0.11 μmol, respectively. Moreover, the reported method is useful in accessing 3,5-bis(4-hydroxy-3-methoxystyryl)-1-phenylpyrazole (2b), which is important in studies related to neuroprotection and Alzheimer's disease, and 2a and 2g, which are inhibitors of protein kinases involved in neuronal excitotoxicity.
NOVEL CURCUMIN DERIVATIVES
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Page 19, (2008/06/13)
The present invention relates to a novel curcumin derivative and a pharmaceutical composition, in particular to a novel curcumin derivative with anti-angiogenic activity and a pharmaceutical composition for treating or preventing a disease associated with unregulated angiogenesis.
