4-(3,5-bis((E)-4-Hydroxy-3-Methoxystyryl)-1H-pyrazol-1-yl)benzoic acid

Base Information

• Chemical Name: 4-(3,5-bis((E)-4-Hydroxy-3-Methoxystyryl)-1H-pyrazol-1-yl)benzoic acid
• CAS No.: 1297655-06-1
• Molecular Formula: C₂₈H₂₄N₂O₆
• Molecular Weight: 484.508
• Mol file: 1297655-06-1.mol

Synonyms:4-(3,5-bis((E)-4-Hydroxy-3-Methoxystyryl)-1H-pyrazol-1-yl)benzoic acid

Chemical Property of 4-(3,5-bis((E)-4-Hydroxy-3-Methoxystyryl)-1H-pyrazol-1-yl)benzoic acid

Chemical Property:

• PSA: 114.04000
• LogP: 5.33970

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3,5-bis((E)-4-Hydroxy-3-Methoxystyryl)-1H-pyrazol-1-yl)benzoic acid

There total 4 articles about 4-(3,5-bis((E)-4-Hydroxy-3-Methoxystyryl)-1H-pyrazol-1-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

curcumin (458-37-7) + 4-Hydrazinobenzoic acid (619-67-0) → 1-(4-carboxyphenyl)-3,5-bis(4-hydroxy-3-methoxystyryl)pyrazole (1297655-06-1)

Guidance literature:

With acetic acid; at 20 ℃; for 0.0166667 - 0.0333333h;

DOI:10.1002/ardp.201500305

Reference yield:

curcumin (458-37-7,94875-80-6) + 4-hydrazinylbenzoic acid hydrochloride → C28H24N2O6 (1297655-06-1)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 8h; Reflux;

DOI:10.1007/s00044-019-02414-5

Reference yield:

vanillin (121-33-5,8014-42-4) → 1-(4-carboxyphenyl)-3,5-bis(4-hydroxy-3-methoxystyryl)pyrazole (1297655-06-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: boric acid / N,N-dimethyl-formamide / 0.17 h / 90 - 95 °C

1.2: 6 h / 90 - 95 °C

2.1: acetic acid / 0.02 - 0.03 h / 20 °C

With boric acid; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1002/ardp.201500305

upstream raw materials:

curcumin

4-Hydrazinobenzoic acid

vanillin

acetylacetone