129768-24-7

Basic information

• Product Name: 1H-Pyrazole-5-carbonyl chloride, 1-methyl-3-(trifluoromethyl)- (9CI)
• Synonyms: 1H-Pyrazole-5-carbonyl chloride, 1-methyl-3-(trifluoromethyl)- (9CI)
• CAS NO: 129768-24-7
• Molecular Formula: C₆H₄ClF₃N₂O
• Molecular Weight: 212.5569696
• Product Categories: ACIDHALIDE
• Mol File: 129768-24-7.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrazole-5-carbonyl chloride, 1-methyl-3-(trifluoromethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-5-carbonyl chloride, 1-methyl-3-(trifluoromethyl)- (9CI)(129768-24-7)
• EPA Substance Registry System: 1H-Pyrazole-5-carbonyl chloride, 1-methyl-3-(trifluoromethyl)- (9CI)(129768-24-7)

Safety Data

• Hazardous Substances Data: 129768-24-7(Hazardous Substances Data)

Usage

Structure

1H-Pyrazole-5-carbonyl chloride, 1-methyl-3-(trifluoromethyl)

Type of compound

Carbonyl chloride derivative of 1-methyl-3-(trifluoromethyl)pyrazole

Usage

Commonly used in organic synthesis and medicinal chemistry

Reactivity

Reactive and versatile reagent utilized in the preparation of a variety of pharmaceuticals and agrochemicals

Physical state at room temperature

White to light yellow solid

Handling precautions

Handle with caution due to potential for hazardous chemical reactions

Importance

Widely used and important chemical in the fields of organic chemistry and drug discovery.

Upstream product

• 154471-65-5 1-methyl-3-trifluoromethylpyrazol 
• 128694-63-3 1-methyl-3-(trifluoromethyl)pyrazole-5-carboxylic acid 

Downstream Products

• 1374007-13-2 N-(4-((2-(hydroxymethyl)phenyl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide 
• 1374006-91-3 N-(4-((2-(3-hydroxypropyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide 
• 1374006-90-2 ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)propanoate 
• 1374006-80-0 N-(4-((2-((methoxymethoxy)methyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide 
• 1374006-95-7 1-methyl-N-(4-((2-(2-morpholinoethyl)piperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)pyrazole-5-carboxamide 
• 1374006-92-4 N-(4-((2-(2-hydroxyethyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide 
• 1374006-84-4 N-(4-((2-(azidomethyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide 
• 1374007-14-3 1-methyl-N-(4-((2-(morpholinomethyl)phenyl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide 
• 1374006-83-3 1-methyl-N-(4-((2-(morpholinomethyl)piperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide 
• 1005780-64-2 N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide 
• 1374006-82-2 N-(4-((4-((methoxymethoxy)methyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide 
• 1374006-81-1 N-(4-((3-((methoxymethoxy)methyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide 
• 1033132-58-9 C₂₁H₂₆F₃N₅O₅S 
• 1045756-48-6 C₁₈H₂₁F₃N₄O₃S 

Relevant articles and documents

An efficient synthesis of isomeric 1-(1-Alkyl-1H-pyrazolyl) ethanones

A simple and versatile general method for the preparation of N-substituted 3-, 4-, or 5-acetylpyrazoles from corresponding acids via hydrolysis and decarboxylation of substituted diethyl [(1-alkyl-1H-pyrazolyl)carbonyl]malonates was developed. Title compounds were prepared in three steps without isolation of intermediates in 48-82% overall yield.

HARMFUL ORGANISM CONTROL COMPOSITION

This invention provides a harmful organism control composition having an excellent harmful organism control effect and comprising as an effective ingredient the following 4-(2-butynyloxy)-5-fluoro-6-(3,5-dimethylpiperidino)-pyrimidine (X): and a hydrazide compound represented by formula (I): wherein A1 and A2 represent, for example, an oxygen atom; R1, R2, and R3 represent, for example, a hydrogen atom, a C1-6 alkyl group optionally substituted by a halogen atom; and Q represents, for example, a methoxycarbonyl group.

Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex activity: Synthesis and in vitro evaluation

High-throughput screening has identified 1-methyl-3-(trifluoromethyl)-N-[4-(pyrrolidinylsulfonyl)phenyl]-1H-pyrazole-5-carboxamide 16677 as a novel and potent (IC50 = 35-145 nM) inhibitor against multiple primary isolates of diverse measles vir