129778-28-5

Upstream product

• 66270-36-8 2,2,2-trichloro-1,1-dimethylethoxychloroformate 
• 90742-20-4 2'-O-tetrahydropyranyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)cytidine 
• 129778-29-6 2'-O-(tetrahydropyran-2-yl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-N⁴-(trichloro-t-butoxycarbonyl)cytidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 129778-30-9 {1-[(2R,3R,4R,5R)-4-Hydroxy-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester 

Downstream Products

• 129808-97-5 {1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(bis-phenylsulfanyl-phosphoryloxy)-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester 

Relevant academic research and scientific papers

Synthesis of cytidyl(3′-5′)adenosine bearing 2′(3′)-O-leucyl ester via a phosphorothioate triester intermediate

2′(3′)-O-(Leucyl)CpA was synthesized in the phosphotriester method. The phenylthio group was used as a protecting group of the Internucleotidic bond. The P-S bond of the triester intermediate was selectively cleaved by using (Bu3Sn)2