Synthesis of cytidyl(3′-5′)adenosine bearing 2′(3′)-O-leucyl ester via a phosphorothioate triester intermediate

Article abstract of DOI:10.1016/S0040-4020(01)86683-7

2′(3′)-O-(Leucyl)CpA was synthesized in the phosphotriester method. The phenylthio group was used as a protecting group of the Internucleotidic bond. The P-S bond of the triester intermediate was selectively cleaved by using (Bu₃Sn)₂