129778-76-3

Upstream product

• 72155-45-4 Boc-L-phenylalaninal 
• 762-72-1 allyl-trimethyl-silane 
• 106-95-6 allyl bromide 
• 160002-06-2 (S)-tert-butyl 3-oxo-1-phenylhex-5-en-2-ylcarbamate 
• 24850-33-7 allyltributylstanane 
• 250669-02-4 anti-(2S,3S)-2-[N-(tert-butoxycarbonyl)amino]-3-dimethylphenylsilyl-1-phenyl-5-hexen-3-ol 
• 87694-53-9 Boc-Phe-OH N,O-dimethyl hydroxamate 
• 250668-93-0 (2S)-3-phenyl-2-[N-(tert-butoxycarbonyl)amino]propanoyldimethylphenylsilane 
• 34101-07-0 (2S)-2-[N-(tert-butoxycarbonyl)amino]-1-imidazol-1-yl-3-phenylpropan-1-one 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Downstream Products

• 113283-84-4 (4S,5R)-4-benzyl-5(1-propenyl)-1,3-oxazolidin-2-one 
• 109579-10-4 (4S,5S)-5-Benzyl-1-(tert-butyloxycarbonyl)-4-hydroxypyrrolidin-2-one 
• 129029-33-0 (4R,5S)-5-Benzyl-4-hydroxy-2-oxopyrrolidine 
• 129029-32-9 (4S,5S)-5-Benzyl-2-oxo-4-hydroxypyrrolidine 
• 109579-09-1 (5S)-5-benzyl-4-hydroxy-1-t-butoxycarbonylpyrrol-2(5H)-one 
• 229981-33-3 tert-butyl (2S,3R)-2-benzyl-3--5-oxo-1-pyrrolidinecarboxylate 
• 111061-10-0 (2S,3R)-2-amino-1-phenyl-5-hexen-3-ol 

Relevant academic research and scientific papers

Mild and efficient allylation of aldehydes with allyltributylstannane promoted by MgI2·(OEt)n etherate

Allylation of aldehydes with allyltributylstannane was promoted in the presence of MgI2·(OEt)n to give homoallylic alcohols. The iodide anion and a noncoordinating reaction medium (CH 2Cl2) are the key features

A facile approach to trans-4,5-pyrrolidine lactam and application in the synthesis of nemonapride and streptopyrrolidine

An efficient approach to trans-4-hydroxylpyrrolidine lactams 1 starting from amino acid is described. The utility of this method has been demonstrated in the synthesis of antipsychotic nemonapride 3 and antiangiogenic streptopyrrolidine 4. Compared four s

A practical route to enantiopure 3-hydroxy-pyrrolidines: application to a straightforward synthesis of (-)-bulgecinine

A practical synthesis of enantiopure substituted 3-hydroxy-pyrrolidines is reported. In four steps, starting from commercially available amino acids as chiral educts, this method allows for an efficient preparation of a variety of 3-hydroxy-pyrrolidines, as well as 3-hydroxy-piperidines and azepanes. Application of this methodology for a straightforward asymmetric synthesis of (-)-bulgecinine is also described.

Allyltrichlorostannane additions to α-amino aldehydes: Application to the total synthesis of the aspartyl protease inhibitors L-682,679, L-684,414, L-685,434, and L-685,458

The hydroxyethylene dipeptide isosteres L-682,679, L-684,414, L-685,434, and L-685,458 were synthesized in a few steps by a sequence involving an allyltrichlorostannane coupling with an α-amino aldehyde, followed by hydroboration of the corresponding 1,2-

CrCl2 mediated addition of allylic halides or phosphates to N-protected α-amino aldehydes. Stereocontrolled synthesis of a new core for C2 symmetric HIV-protease inhibitors

The addition of γ-monosubstituted allylchromium(III) reagents to N-protected α-amino aldehydes proceeds in a stereoconvergent manner in contrast with the case of the unsubstituted reagents, where the stereoselectivity depends on the nature of the group bo

Addition of Allylic Metals to α-Aminoaldehydes. Application to the Synthesis of Statine, Ketomethylene and Hydroxyethylene Dipeptide Isosteres

A general and stereoselective method to statine, ketomethylene and hydroxyethylene dipeptide isosteres is described.The key reaction is the diastereoselective allyl metal addition to α-aminoaldehydes.